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Association of Vitamin D Supplementation and Periodontitis in Iranian Adults: A Case-control Study
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Seyyede Tarannom Maddah   , Zahra Ghorbani * , Azade Esmaeilnejad |
| Department of Community Oral Health, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , tarmaddah@gmail.com |
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Abstract: (98 Views) |
Background and Objectives: Vitamin D may include a role in periodontal health. This study aimed to assess association of vitamin D supplement intake and periodontitis in Iranian adults.
Materials and Methods: This was a case-control study comprising 150 participants aged 35–44 years from the two sexes, who were non-smokers, non-diabetics and enquirers of dental treatment at a dental public health center. First, condition of periodontium was assessed using clinical attachment loss, probing depth, bleeding on probing and plaque index. Participants were grouped to normal (n1 = 75) and chronic periodontitis (n2 = 75) groups. Data on tooth brushing and flossing, body weight and height, history of periodontal treatment, regular dental visits, insurance status and regular vitamin D supplementation in past 3 y were collected using questionnaires. Chi square, t-student test and logistic regression were used for statistical analyses.
Results: Those who had regular vitamin D intake, experienced periodontitis less than those who did not (78.7% against 33.3%, P-value < 0.0001). Results of logistic regression analysis showed that after adjusting for all assessed variables, not taking vitamin D supplements (OR = 5.33) and brushing less than once a day (OR = 8.01) variables were independently associated to the development of periodontitis.
Conclusions: These results have shown that regular intake of vitamin D is independently linked to the periodontal health in adults. |
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| Keywords: Periodontitis, Tooth brushing, Vitamin D, Supplement |
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Full-Text [PDF 566 kb]
(62 Downloads)
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Article type: Research |
Subject:
Nutrition
Received: 2024/09/8 | Accepted: 2024/09/24 | Published: 2025/02/9
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- Vitamin D may include a role in periodontal health.
- In this case-control study, those participants with regular vitamin D intake experienced periodontitis less than those who did not (78.7% against 33.3%, P-value < 0.0001).
- After adjusting for all assessed variables, not taking vitamin D supplements (OR = 5.33) and brushing less than once a day (OR = 8.01) variables were independently associated with the development of periodontitis.
- Optimizing vitamin D status through supplementation may be addressed as a preventive strategy against periodontitis.
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| References |
1. Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. European journal of clinical nutrition. 2020;74(11):1498-513. [ DOI:10.1038/s41430-020-0558-y] 2. Neyestani TR, Hajifaraji M, Omidvar N, Eshraghian MR, Shariatzadeh N, Kalayi A, et al. High prevalence of vitamin D deficiency in school-age children in Tehran, 2008: a red alert. Public Health Nutrition. 2012;15(2):324-30. [ DOI:10.1017/S1368980011000188] 3. Nikooyeh B, Abdollahi Z, Hajifaraji M, Alavi-Majd H, Salehi F, Yarparvar AH, et al. Vitamin D Status, Latitude and their Associations with Some Health Parameters in Children: National Food and Nutrition Surveillance. J Trop Pediatr. 2017;63(1):57-64. [ DOI:10.1093/tropej/fmw057] 4. Nikooyeh B, Abdollahi Z, Hajifaraji M, Alavi-Majd H, Salehi F, Yarparvar AH, et al. Vitamin D status and cardiometabolic risk factors across latitudinal gradient in Iranian adults. Nutr Health. 2017:260106017702918. [ DOI:10.1177/0260106017702918] 5. Nikooyeh B, Hajifaraji M, Yarparvar A-H, Abdollahi Z, Sahebdel M, Dehkordi AM, et al. Hypovitaminosis D in adults living in a Sunny City: Relation to some cardiometabolic risk factors, national food and nutrition surveillance. Nutrition and Food Sciences Research. 2018;5(1):9-14. [ DOI:10.29252/nfsr.5.1.9] 6. Nikooyeh B, Neyestani TR. What is the definition of" vitamin D deficiency" and who is considered" vitamin D deficient"? Urgent need for a national consensus. Nutrition and Food Sciences Research. 2017;4(2):1-5. [ DOI:10.18869/acadpub.nfsr.4.2.1] 7. Yari Z, Nikooyeh B, Ebrahimof S, Neyestani TR. Global Burden of Disease, the Heavy Cost of Sun Deprivation: Implications for Mass Food Fortification with Vitamin D. Applications of Functional Foods and Nutraceuticals for Chronic Diseases: CRC Press; 2023. p. 67-116. [ DOI:10.1201/9781003220053-6] 8. Ranaei V, Pilevar Z, Neyestani TR. Can raising vitamin D status slow down Covid-19 waves? Nutrition and Food Sciences Research. 2021;8(1):1-3. 9. Frencken JE, Sharma P, Stenhouse L, Green D, Laverty D, Dietrich T. Global epidemiology of dental caries and severe periodontitis-a comprehensive review. Journal of clinical periodontology. 2017;44:S94-S105. [ DOI:10.1111/jcpe.12677] 10. Yang H, Xiao L, Zhang L, Deepal S, Ye G, Zhang X. Epidemic trend of periodontal disease in elderly Chinese population, 1987-2015: a systematic review and meta-analysis. Scientific reports. 2017;7(1):45000. [ DOI:10.1038/srep45000] 11. Collaborators GOD, Bernabe E, Marcenes W, Hernandez C, Bailey J, Abreu L, et al. Global, regional, and national levels and trends in burden of oral conditions from 1990 to 2017: a systematic analysis for the global burden of disease 2017 study. Journal of dental research. 2020;99(4):362-73. [ DOI:10.1177/0022034520908533] 12. Nascimento GG, Leite FR, Scheutz F, López R. Periodontitis: from infection to inflammation. Current Oral Health Reports. 2017;4:301-8. [ DOI:10.1007/s40496-017-0158-7] 13. Casarin M, Da Silveira TM, Bezerra B, Pirih FQ, Pola NM. Association between different dietary patterns and eating disorders and periodontal diseases. Frontiers in Oral Health. 2023;4:1152031. [ DOI:10.3389/froh.2023.1152031] 14. Sarlati F, Akhondi N, Ettehad T, Neyestani T, Kamali Z. Relationship between obesity and periodontal status in a sample of young Iranian adults. International dental journal. 2008;58(1):36-40. 15. Khoshnevisan M, Ghasemianpour M, Samadzadeh H, Baez R. Oral health status and healthcare system in IR Iran. J Contemp Med Sci. 2018;4(3):107-18. 16. Perić M, Cavalier E, Toma S, Lasserre J. Serum vitamin D levels and chronic periodontitis in adult, Caucasian population-a systematic review. Journal of periodontal research. 2018;53(5):645-56. [ DOI:10.1111/jre.12560] 17. Machado V, Lobo S, Proença L, Mendes JJ, Botelho J. Vitamin D and periodontitis: A systematic review and meta-analysis. Nutrients. 2020;12(8):2177. [ DOI:10.3390/nu12082177] 18. Khammissa R, Ballyram R, Jadwat Y, Fourie J, Lemmer J, Feller L. Vitamin D deficiency as it relates to oral immunity and chronic periodontitis. International journal of dentistry. 2018;2018(1):7315797. [ DOI:10.1155/2018/7315797] 19. Anbarcioglu E, Kirtiloglu T, Öztürk A, Kolbakir F, Acıkgöz G, Colak R. Vitamin D deficiency in patients with aggressive periodontitis. Oral diseases. 2019;25(1):242-9. [ DOI:10.1111/odi.12968] 20. Rafique S, Khan S, Ahmed S, Qureshi MA, Amin R. Case-control study for assessment of factors associated with periodontitis among adults attending a university hospital in Karachi, Pakistan. J Pak Med Assoc. 2021;71(1(b)):525-256. [ DOI:10.47391/JPMA.568] 21. Natto ZS, Abu Ahmad RH, Alsharif LT, Alrowithi HF, Alsini DA, Salih HA, et al. Chronic periodontitis case definitions and confounders in periodontal research: a systematic assessment. BioMed research international. 2018;2018(1):4578782. [ DOI:10.1155/2018/4578782] 22. Li A, Thomas RZ, van der Sluis L, Tjakkes GH, Slot DE. Definitions used for a healthy periodontium-a systematic review. International Journal of Dental Hygiene. 2020;18(4):327-43. [ DOI:10.1111/idh.12438] 23. Olszewska-Czyz I, Firkova E. Vitamin D3 serum levels in periodontitis patients: a case-control study. Medicina. 2022;58(5):585. [ DOI:10.3390/medicina58050585] 24. Dietrich T, Nunn M, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. The American journal of clinical nutrition. 2005;82(3):575-80. [ DOI:10.1093/ajcn/82.3.575] 25. Hagenau T, Vest R, Gissel TN, Poulsen CS, Erlandsen M, Mosekilde L, et al. Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int. 2009;20(1):133-40. [ DOI:10.1007/s00198-008-0626-y] 26. Antonoglou GN, Suominen AL, Knuuttila M, Ylöstalo P, Ojala M, Männistö S, et al. Associations between serum 25‐hydroxyvitamin d and periodontal pocketing and gingival bleeding: results of a study in a non‐smoking population in Finland. Journal of periodontology. 2015;86(6):755-65. [ DOI:10.1902/jop.2015.140262] 27. Shirmohammadi A, Mohammadi S, Faramarzi M, Babaloo AR, Sadighi M, Dizaj SM. Association of Serum 25-Hydroxyvitamin D and Chronic Periodontitis in Postmenopausal Women after Non-Surgical Periodontal Therapy. Frontiers in Dentistry. 2023;20. [ DOI:10.18502/fid.v20i8.12607] 28. Liang F, Zhou Y, Zhang Z, Zhang Z, Shen J. Association of vitamin D in individuals with periodontitis: an updated systematic review and meta-analysis. BMC Oral Health. 2023;23(1):387. [ DOI:10.1186/s12903-023-03120-w] 29. Moura-Grec PGd, Marsicano JA, Carvalho CAPd, Sales-Peres SHdC. Obesity and periodontitis: systematic review and meta-analysis. Ciencia & saude coletiva. 2014;19:1763-72. [ DOI:10.1590/1413-81232014196.13482013] 30. Nascimento GG, Leite FR, Do LG, Peres KG, Correa MB, Demarco FF, et al. Is weight gain associated with the incidence of periodontitis? A systematic review and meta‐analysis. Journal of clinical periodontology. 2015;42(6):495-505. [ DOI:10.1111/jcpe.12417] 31. Matarese G, Isola G, Anastasi GP, Favaloro A, Milardi D, Vermiglio G, et al. Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: a role of these biomarkers in the pathogenesis of scleroderma and periodontal disease. International journal of molecular medicine. 2012;30(3):502-8. [ DOI:10.3892/ijmm.2012.1024] 32. Isola G, Giudice AL, Polizzi A, Alibrandi A, Patini R, Ferlito S. Periodontitis and tooth loss have negative systemic impact on circulating progenitor cell levels: a clinical study. Genes. 2019;10(12):1022. [ DOI:10.3390/genes10121022] 33. Jagelavičienė E, Vaitkevičienė I, Šilingaitė D, Šinkūnaitė E, Daugėlaitė G. The relationship between vitamin D and periodontal pathology. Medicina. 2018;54(3):45. [ DOI:10.3390/medicina54030045] 34. Schwalfenberg GK. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Molecular nutrition & food research. 2011;55(1):96-108. [ DOI:10.1002/mnfr.201000174] 35. Matarese G, Ramaglia L, Fiorillo L, Cervino G, Lauritano F, Isola G. Implantology and periodontal disease: the panacea to problem solving? The Open Dentistry Journal. 2017;11:460. [ DOI:10.2174/1874210601711010460] 36. Perić M, Maiter D, Cavalier E, Lasserre JF, Toma S. The effects of 6-month vitamin D supplementation during the non-surgical treatment of periodontitis in vitamin-D-deficient patients: a randomized double-blind placebo-controlled study. Nutrients. 2020;12(10):2940. [ DOI:10.3390/nu12102940] |
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Maddah S T, Ghorbani Z, Esmaeilnejad A. Association of Vitamin D Supplementation and Periodontitis in Iranian Adults: A Case-control Study. Nutr Food Sci Res 2025; 12 (1) :39-44 URL: http://nfsr.sbmu.ac.ir/article-1-633-en.html
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