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:: Volume 8, Issue 1 (Jan-Mar 2021) ::
Nutr Food Sci Res 2021, 8(1): 29-34 Back to browse issues page
Clinical and Laboratory Surveys of the Iranian Celiac Patients
Manoochehr Karami , Behrooz Afshar , Alireza Monsef Esfahani , Saeed Bashirian , Leyla Halimi
Clinical Research Development Unit of Shahid Beheshti Hospital, Hamadan University of Medical Science, Hamadan, Iran
Abstract:   (196 Views)
Background and Objectives: As an autoimmune disease, celiac is triggered by exposure to dietary gluten in genetically susceptible individuals, leading to various gastrointestinal and non-gastrointestinal symptoms. The aim of the current study was to accurately investigate epidemiology of the celiac disease in Hamadan Province, Iran.
Materials and Methods: This study was carried out as a case series at Hamadan University of Medical Sciences, Hamadan, Iran, 2016–2018. The participants were selected using census method. Data analysis was carried out using SPSS Software v.18 and descriptive statistics.
Results: From 72 participants, 68.1% were females and 31.9% were males. In addition, the mean age of the participants was 32.47 y ±17.21; 15.27% of them had known genetic backgrounds. Serological results revealed that 47% of the participants had tTG antibody. Based on the disease severity classification, the highest frequency (57%) was linked to Marsh III. Furthermore, 10% of celiac patients were simultaneously diagnosed with diabetes.
Conclusions: In this study, celiac was mostly diagnosed in young to middle-age people (30–40 y), the majority of whom were females. It seems that the incidence of diabetes and CD is one of the most significant health problems in the province. High severity of the disease (Marsh III) was important as well. Of the disease symptoms, gastrointestinal symptoms were more common; from which, diarrhea and abdominal pain were more common. In non-gastrointestinal symptoms, anemia was the most common symptom.
Keywords: Clinical and laboratory characteristics, Celiac disease (CD), Gluten, Transglutaminase, Diet, Anemia
Full-Text [PDF 424 kb]   (61 Downloads)    
Protocol Study: Research | Subject: nutrition
Received: 2020/08/4 | Accepted: 2020/09/11 | Published: 2021/01/3
1. Kelly CP, Bai JC, Liu E, Leffler DA. Advances in diagnosis and management of celiac disease. Gastroenterology. 2015;148(6):1175-86. [DOI:10.1053/j.gastro.2015.01.044]
2. Rastogi A, Bhadada SK, Bhansali A, Kochhar R, Santosh R. Celiac disease: a missed cause of metabolic bone disease. Indian journal of endocrinology and metabolism. 2012;16(5):780. [DOI:10.4103/2230-8210.100674]
3. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nature medicine. 1997;3(7):797. [DOI:10.1038/nm0797-797]
4. Mogul D, Nakamura Y, Seo J, Blauvelt B, Bridges JF. The unknown burden and cost of celiac disease in the US. Expert review of pharmacoeconomics & outcomes research. 2017;17(2):181-8. [DOI:10.1080/14737167.2017.1314785]
5. Biagi F, Gobbi P, Marchese A, Borsotti E, Zingone F, Ciacci C, et al. Low incidence but poor prognosis of complicated coeliac disease: a retrospective multicentre study. Digestive and Liver Disease. 2014;46(3):227-30. [DOI:10.1016/j.dld.2013.10.010]
6. Hopper AD, Hadjivassiliou M, Hurlstone DP, Lobo AJ, McAlindon ME, Egner W, et al. What is the role of serologic testing in celiac disease? A prospective, biopsy-confirmed study with economic analysis. Clinical Gastroenterology and Hepatology. 2008;6(3):314-20. [DOI:10.1016/j.cgh.2007.12.008]
7. Charlesworth RPG, Agnew LL, Scott DR, Andronicos NM. Celiac disease gene expression data can be used to classify biopsies along the Marsh score severity scale. Journal of Gastroenterology and Hepatology.34(1):169-77. [DOI:10.1111/jgh.14369]
8. Oberhuber G. Histopathology of celiac disease. Biomedicine & pharmacotherapy. 2000;54(7):368-72. [DOI:10.1016/S0753-3322(01)80003-2]
9. Aletaha N, POURSHAMS A, Shahbazkhani B. Celiac Disease. 2007.
10. Catassi C, Rätsch I, Fabiani E, Rossini M, Coppa G, Giorgi P, et al. Coeliac disease in the year 2000: exploring the iceberg. The Lancet. 1994;343(8891):200-3. [DOI:10.1016/S0140-6736(94)90989-X]
11. Green PH, Jabri B. Coeliac disease. The Lancet. 2003;362(9381):383-91. [DOI:10.1016/S0140-6736(03)14027-5]
12. James MW, Scott BB. Coeliac disease: the cause of the various associated disorders? European journal of gastroenterology & hepatology. 2001;13(9):1119-21. [DOI:10.1097/00042737-200109000-00022]
13. Shahbazkhani B, Mehrabi G, Nasiritosi M, Forotan H, Asefirad S. Celiac disease in cryptogenic hypertransaminasemia. Tehran University Medical Journal. 2010;68(7).
14. Ahmadi B, Zaherara M. Prevalence of celiac disease in patients with irritable bowel syndrome in Kerman. Iran J Kerman Univ Med Sci. 2015;20(3):319-27.
15. Khoshnia M, Pourshams A, Mohammadkhani A, Tavangar S, Shahbazkhani B, Malekzadeh R. Celiac disease in gonbad-kavoos. Govaresh. 2012;10(3):131-3.
16. Akbari MR, Mohammadkhani A, Fakheri H, Zahedi MJ, Shahbazkhani B, Nouraie M, et al. Screening of the adult population in Iran for coeliac disease: comparison of the tissue-transglutaminase antibody and anti-endomysial antibody tests. European journal of gastroenterology & hepatology. 2006;18(11):1181-6. [DOI:10.1097/01.meg.0000224477.51428.32]
17. Tursi A, Brandimarte G, Giorgetti GM. Prevalence of antitissue transglutaminase antibodies in different degrees of intestinal damage in celiac disease. Journal of clinical gastroenterology. 2003;36(3):219-21. [DOI:10.1097/00004836-200303000-00007]
18. Nejad MR, Rostami K, Emami MH, Zali MR, Malekzadeh R. Epidemiology of celiac disease in Iran: a review. Middle East Journal of Digestive Diseases. 2011;3(1):5.
19. Collin P, Kaukinen K, Välimäki M, Salmi J. Endocrinological disorders and celiac disease. Endocrine reviews. 2002;23(4):464-83. [DOI:10.1210/er.2001-0035]
20. Greco L, Romino R, Coto I, Di Cosmo N, Percopo S, Maglio M, et al. The first large population based twin study of coeliac disease. Gut. 2002;50(5):624-8. [DOI:10.1136/gut.50.5.624]
21. O'leary C, Walsh C, Wieneke P, O'regan P, Buckley B, O'halloran D, et al. Coeliac disease and autoimmune Addison's disease: a clinical pitfall. Qjm. 2002;95(2):79-82. [DOI:10.1093/qjmed/95.2.79]
22. Sheikholeslami H BK, Hashemipoor S, Hadjmanoochehri F, Ziaii A. COMPARING FREQUENCY OF CELIAC DISEASE IN PATIENTS WITH DIABETES MELLITUS TYPE I AND NON-DIABETIC , HEALTHY PERSONS. Iranian Journal of Diabetes and Metabolism. 2005;4(3):49-55.
23. Schuppan D, Hahn EG. Celiac disease and its link to type 1 diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism. 2001;14(Supplement):597-606. [DOI:10.1515/JPEM.2001.14.S1.597]
24. Al-Ashwal AA, Shabib SM, Sakati NA, Attia NA. Prevalence and characteristics of celiac disease in type 1 diabetes mellitus in Saudi Arabia. Saudi medical journal. 2003;24(10):1113-5.
25. Shahbazkhani B, Faezi T, Akbari M, Mohamadnejad M, Sotoudeh M, Rajab A, et al. Coeliac disease in Iranian type I diabetic patients. Digestive and liver disease. 2004;36(3):191-4. [DOI:10.1016/j.dld.2003.10.015]
26. Catassi C, Kryszak D, Louis-Jacques O, Duerksen DR, Hill I, Crowe SE, et al. Detection of celiac disease in primary care: a multicenter case-finding study in North America. American Journal of Gastroenterology. 2007;102(7):1454-60. [DOI:10.1111/j.1572-0241.2007.01173.x]
27. Collin P, Rasmussen M, Kyrأ¶npalo S, Laippala P, Kaukinen K. The hunt for coeliac disease in primary care. Qjm. 2002;95(2):75-7. [DOI:10.1093/qjmed/95.2.75]
28. Hin H, Bird G, Peter F, Mahy N, Jewell D. Coeliac disease in primary care: case finding study. Bmj. 1999;318(7177):164-7. [DOI:10.1136/bmj.318.7177.164]
29. Berti I, Della Vedova R, Paduano R, Devetta M, Caradonna M, Villanacci V, et al. Coeliac disease in primary care: evaluation of a case-finding strategy. Digestive and Liver Disease. 2006;38(7):461-7. [DOI:10.1016/j.dld.2005.12.007]
30. Sanders DS, Patel D, Stephenson TJ, Ward AM, McCloskey EV, Hadjivassiliou M, et al. A primary care cross-sectional study of undiagnosed adult coeliac disease. European journal of gastroenterology & hepatology. 2003;15(4):407-13. [DOI:10.1097/00042737-200304000-00012]
31. Rawashdeh M, Khalil B, Raweily E. Celiac disease in Arabs. Journal of pediatric gastroenterology and nutrition. 1996;23(4):415-8. [DOI:10.1097/00005176-199611000-00009]
32. Qari FA. Clinical presentation of adult celiac disease in Western Saudi Arabia. Saudi medical journal. 2002;23(12):1514-7.
33. Rostami K, Shahbazkhani B, Malekzadeh R. Microenteropathy; the entity of the new millennium. Overview of the second asian symposium on coeliac disease, October 18-21, 2003, Tehran. Romanian journal of gastroenterology. 2004;13(1):29.
34. Sima H, Hekmatdoost A, Ghaziani T. Seroprevalence of coelic disease among autoimmune and HBV chronic hepatitis in Tehran Iran. Govaresh. 2003;7:237.
35. Nasr K, Haghighi P, Abadi P, Lahimgarzadeh A, Hedayati H, Halstead J, et al. Idiopathic enteropathy: an evaluation in rural Iran with an appraisal of nutrient loss. The American journal of clinical nutrition. 1976;29(2):169-76. [DOI:10.1093/ajcn/29.2.169]
36. Shahbazkhani B, Forootan M, Merat S, Akbari M, Nasserimoghadam S, Vahedi H, et al. Coeliac disease presenting with symptoms of irritable bowel syndrome. Alimentary pharmacology & therapeutics. 2003;18(2):231-5. [DOI:10.1046/j.1365-2036.2003.01666.x]
37. Shahbazkhani B, Malekzadeh R, Sotoudeh M, Moghadam KF, Farhadi M, Ansari R, et al. High prevalence of coeliac disease in apparently healthy Iranian blood donors. European journal of gastroenterology & hepatology. 2003;15(5):475-8. [DOI:10.1097/00042737-200305000-00003]
38. Nikpour Sh MHE. Prevalence of Celiac Disease in Patients with Idiopathic Iron Deficiency of Referred to Gastroenterology Clinic. Journal of Isfahan Medical School.25(84):10-5.
39. Akbari MR MA, Fakheri H, Javad Zahedi, M SB, Nouraie M, et al. Screening of the adult population in Iran for coeliac disease: comparison of the tissue-transglutaminase antibody and anti-endomysial antibody tests. Eur J Gastroenterol Hepatol 2006;18(11):1181-6. [DOI:10.1097/01.meg.0000224477.51428.32]
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Karami M, Afshar B, Monsef Esfahani A, Bashirian S, Halimi L. Clinical and Laboratory Surveys of the Iranian Celiac Patients. Nutr Food Sci Res. 2021; 8 (1) :29-34
URL: http://nfsr.sbmu.ac.ir/article-1-438-en.html

Volume 8, Issue 1 (Jan-Mar 2021) Back to browse issues page
Nutrition and Food Sciences Research
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