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:: Volume 8, Issue 1 (Jan-Mar 2021) ::
Nutr Food Sci Res 2021, 8(1): 21-28 Back to browse issues page
Effects of Vitamin C Supplementation on C-Reactive Protein, Lactate and Blood Pressure Following Resistance Exercise in Overweight Men
Mehdi Hakimi , Araz Mohammadi
Assistant Professor of Exercise Physiology of Cardiovascular and Respiration, Department of Physical Education & Sport Science, Marivan Branch, Islamic Azad University, Marivan, Iran.
Abstract:   (447 Views)
Background and Objectives: Strenuous exercises have been shown to induce inflammation. However, consumption of products rich in antioxidants such as vitamin C may enhance this effect. The purpose of this study was to assess effects of vitamin C supplementation on C-reactive protein, lactate and blood pressure following resistance exercise in overweight men.
Materials and Methods: In a randomized, double-blinded placebo-controlled trial, 20 young men (age of 38.8 y ±3.4 and BMI of 28.36 kg/m2 ±1.2) voluntarily participated and were randomly divided into vitamin C supplementation
(n = 10) and placebo (n = 10) groups. After two weeks of receiving 500 mg/d of vitamin C or placebo, participants were involved in a session of resistance exercises (three sets of eight repetitions at 80% of one repetition maximum). To assess changes in C-reactive protein and lactate, blood samples were collected after blood pressure measurement at phases of baseline, pre exercise, immediately post resistance exercise and 24 h post exercise.
Results: Results using ANOVA with repeated measurement showed that levels of C-reactive protein, lactate and systolic and diastolic blood pressure were not significantly changed in participants after supplementation (p>0.05). Moreover, significant increases were seen in lactate and systolic and diastolic blood pressure immediately after exercise intervention in both groups (p < 0.05). However, C-reactive protein levels significantly increased only in placebo group immediately post resistance exercise and 24 h post exercise, compared to those at baseline (p = 0.008 and p = 0.021, respectively) and pre exercise (p = 0.007, and p = 0.019, respectively) times. The unique statistically significant difference between the two groups included a significant increase in level of C-reactive protein in placebo group immediately post resistance exercise (p = 0.031) and 24 h post exercise (p = 0.038) times, compared to supplement group.
Conclusions: Results from the present study have demonstrated the beneficial effects of vitamin C supplement on improved blood pressure and lactate tolerance as well as decreased inflammatory responses of C-reactive protein caused by resistance exercises.
Keywords: Physical activity, Inflammation, Blood pressure, Lactic Acid, CRP
Full-Text [PDF 575 kb]   (206 Downloads)    
Article type: Research | Subject: nutrition
Received: 2020/05/20 | Accepted: 2020/08/23 | Published: 2021/01/3
1. Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Archives of internal medicine. 2002;162(16):1867-72. [DOI:10.1001/archinte.162.16.1867]
2. Welsh P, Grassia G, Botha S, Sattar N, Maffia P. Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? British Journal of Pharmacology. 2017;174(22):3898-913. [DOI:10.1111/bph.13818]
3. Bahadursingh S, Beharry K, Maharaj K, Mootoo C, Sharma P, Singh J, et al. C-reactive protein: adjunct to cardiovascular risk assessment. West indian medical Journal. 2009;58(6):551-4.
4. Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, et al. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. The American journal of clinical nutrition. 2004;79(4):544-51. [DOI:10.1093/ajcn/79.4.544]
5. Calabró P, Willerson JT, Yeh ET. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation. 2003;108(16):1930-2. [DOI:10.1161/01.CIR.0000096055.62724.C5]
6. Wang C-H, Li S-H, Weisel RD, Fedak PW, Dumont AS, Szmitko P, et al. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation. 2003;107(13):1783-90. [DOI:10.1161/01.CIR.0000061916.95736.E5]
7. Cottone S, Mulè G, Nardi E, Vadalà A, Guarneri M, Briolotta C, et al. Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension. American journal of hypertension. 2006;19(3):313-8. [DOI:10.1016/j.amjhyper.2005.09.005]
8. Brown CM, Turner ST, Bailey KR, Mosley Jr TH, Kardia SL, Wiste HJ, et al. Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life. Journal of hypertension. 2013;31(11):2213. [DOI:10.1097/HJH.0b013e3283642f6c]
9. Craig G, Rollins BJ. Chemokines and disease. Nature immunology. 2001;2(2):108. [DOI:10.1038/84209]
10. Ernberg M, Christidis N, Ghafouri B, Bileviciute-Ljungar I, Löfgren M, Larsson A, et al. Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia. Arthritis Research & Therapy. 2016;18(1):137. [DOI:10.1186/s13075-016-1041-y]
11. Ramel A, Geirsdottir O, Jonsson P, Thorsdottiri I. C-reactive protein and resistance exercise in community dwelling old adults. The journal of nutrition, health & aging. 2015;19(7):792-6. [DOI:10.1007/s12603-015-0548-2]
12. Cormie P, Singh B, Hayes S, Peake JM, Galvão DA, Taaffe DR, et al. Acute inflammatory response to low-, moderate-, and high-load resistance exercise in women with breast cancer-related lymphedema. Integrative cancer therapies. 2016;15(3):308-17. [DOI:10.1177/1534735415617283]
13. Bizheh N, Jaafari M. The effect of a single bout circuit resistance exercise on homocysteine, hs-CRP and fibrinogen in sedentary middle aged men. Iranian journal of basic medical sciences. 2011;14(6):568.
14. Poorabedi Naeini P, Taghian F. The Effect of Consuming 500 mL Low-Fat Milk on Cortisol Response and Salivary CRP After Resistance Training Among Young Healthy Women. Mod Care J. 2018;15(4):e86732. [DOI:10.5812/modernc.86732]
15. Lu J, Wang X-y, Tang W-h. Glutamine attenuates nitric oxide synthase expression and mitochondria membrane potential decrease in interleukin-1β-activated rat hepatocytes. European journal of nutrition. 2009;48(6):333-9. [DOI:10.1007/s00394-009-0018-x]
16. Tan BL, Norhaizan ME, Liew W-P-P. Nutrients and Oxidative Stress: Friend or Foe? Oxidative medicine and cellular longevity. 2018;2018. [DOI:10.1155/2018/9719584]
17. Kawamura T, Muraoka I. Exercise-induced oxidative stress and the effects of antioxidant intake from a physiological viewpoint. Antioxidants. 2018;7(9):119. [DOI:10.3390/antiox7090119]
18. Wannamethee SG, Lowe GD, Rumley A, Bruckdorfer KR, Whincup PH. Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis-. The American journal of clinical nutrition. 2006;83(3):567-74. [DOI:10.1093/ajcn.83.3.567]
19. Juraschek SP, Guallar E, Appel LJ, Miller III ER. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. The American journal of clinical nutrition. 2012;95(5):1079-88. [DOI:10.3945/ajcn.111.027995]
20. Monica Rahardjo T, Redjeki I, Maskoen T. Effect of vitamin C 1000 mgIV therapy to lactate level, base deficit and SVO2in septic patient Critical Care Medicine. 2013;41(12):A283. [DOI:10.1097/01.ccm.0000440354.99718.28]
21. Patlar S, Baltaci AK, Mogulkoc R, Gunay M. Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise. Annals of Applied Sport Science. 2017;5(2):21-7. [DOI:10.18869/acadpub.aassjournal.5.2.21]
22. Biniaz V, Shermeh MS, Ebadi A, Tayebi A, Einollahi B. Effect of vitamin C supplementation on C-reactive protein levels in patients undergoing hemodialysis: A randomized, double blind, placebo-controlled study. Nephro-Urology Monthly. 2014;6(1). [DOI:10.5812/numonthly.13351]
23. Block G, Jensen CD, Dalvi TB, Norkus EP, Hudes M, Crawford PB, et al. Vitamin C treatment reduces elevated C-reactive protein. Free Radical Biology and Medicine. 2009;46(1):70-7. [DOI:10.1016/j.freeradbiomed.2008.09.030]
24. Brzycki M. A practical approach to strength training: Contemporary Books; 1995.
25. Khurana E, Oommen E. Determination of cardiovascular fitness in young healthy medical students. International Archives of Integrated Medicine. 2016;3(10):74-8.
26. Hakimi M, Siahkouhian M, Bolboli L, Sheikholeslami Vatani D. Investigation and comparison of the effects of eight weeks of resistance and endurance training with vitamin D3 supplementation on blood pressure, resting heart rate, and body composition in obese hypertensive middle-aged men. Journal of Clinical Research in Paramedical Sciences. 2018;7(1):e79971. [DOI:10.5812/jcrps.79971]
27. Church TS, Earnest CP, Wood KA, Kampert JB. Reduction of C-reactive protein levels through use of a multivitamin. The American journal of medicine. 2003;115(9):702-7. [DOI:10.1016/j.amjmed.2003.08.024]
28. Choudhuri D, Choudhuri S. Effect of vitamin C supplementation on aerobic capacity, blood pressure and pulmonary functions in young male subjects. Eur J Sport Sci. 2013;2(2):6-11.
29. Hosseini SA, Hosseinin ZS, Noura M, Keikhosravi F, Hassanpour G, Azarbayjani MA, et al. Theeffect of vitamin C and E supplementation on CRP, IL-6, lymphocyte, cortisol and lactate response following one aerobic training session. Journal of Pharmaceutical and Health Sciences 2012;1(4):229-44.
30. Bautista L. Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence. Journal of human hypertension. 2003;17(4):223. [DOI:10.1038/sj.jhh.1001537]
31. Joyner MJ, Casey DP. Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs. Physiological reviews. 2015. [DOI:10.1152/physrev.00035.2013]
32. Bruce RA, Kusumi F, Hosmer D. Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. American heart journal. 1973;85(4):546-62. [DOI:10.1016/0002-8703(73)90502-4]
33. Ratamess NA, Kraemer WJ, Volek JS, Maresh CM, VanHeest JL, Sharman MJ, et al. Androgen receptor content following heavy resistance exercise in men. The Journal of steroid biochemistry and molecular biology. 2005;93(1):35-42. [DOI:10.1016/j.jsbmb.2004.10.019]
34. Atashak S, Sharafi H, Azarbayjani MA, Stannard SR, Goli MA, Haghighi MM. Effect of omega-3 supplementation on the blood levels of oxidative stress, muscle damage and inflammation markers after acute resistance exercise in young athletes. Kinesiology: International Journal of Fundamental and Applied Kinesiology. 2013;45(1):22-9.
35. Phillips T, Childs AC, Dreon DM, Phinney S, Leeuwenburgh C. A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Medicine and science in sports and exercise. 2003;35(12):2032-7. [DOI:10.1249/01.MSS.0000099112.32342.10]
36. Ahmadi F. The effect of four weeks of vitamin C supplementation on the total antioxidant capacity and serum lactate of women active after eccentric exercise. Annals of Military and Health Sciences Research. 2016;14(4). [DOI:10.5812/amh.59399]
37. Patrick A. Funcion and activation of NF-κB in the immune system. annual review of immunology. 1994:141-79. [DOI:10.1146/annurev.iy.12.040194.001041]
38. Fischer CP, Hiscock NJ, Penkowa M, Basu S, Vessby B, Kallner A, et al. Supplementation with vitamins C and E inhibits the release of interleukin 6 from contracting human skeletal muscle. The Journal of physiology. 2004;558(2):633-45. [DOI:10.1113/jphysiol.2004.066779]
39. Härtel C, Strunk T, Bucsky P, Schultz C. Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Cytokine. 2004;27(4-5):101-6. [DOI:10.1016/j.cyto.2004.02.004]
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Hakimi M, Mohammadi A. Effects of Vitamin C Supplementation on C-Reactive Protein, Lactate and Blood Pressure Following Resistance Exercise in Overweight Men. Nutr Food Sci Res. 2021; 8 (1) :21-28
URL: http://nfsr.sbmu.ac.ir/article-1-410-en.html

Volume 8, Issue 1 (Jan-Mar 2021) Back to browse issues page
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