[Home ] [Archive]    
:: Main :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 7, Issue 3 (Jul-Sep 2020) ::
Nutr Food Sci Res 2020, 7(3): 1-7 Back to browse issues page
Associations between Dietary Total Antioxidant Capacity and Risk of Nonalcoholic Fatty Liver Disease (NAFLD) in Adults: A Case-Control Study
MohammadHassan Sohouli , Somaye Fatahi
iran university of medical scinces
Abstract:   (442 Views)
Background and Objectives: Dietary total antioxidant capacity (DTAC) is suggested as a useful tool for the assessment of relationships between cumulative antioxidant food capacities and several chronic disorders. However, relationships between the total antioxidant capacity of the diet (TAC) and the risk of NAFLD has not previously been assessed. The aim of this study was to assess relationships between DTAC and risk of NAFLD in a case-control study.
Materials and Methods: This case-control study was carried out on 158 patients with NAFLD and 357 healthy individuals aged 18–55 years. Dietary data were collected using validated 168- items quantitative food frequency questionnaires. Triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and fasting blood glucose (FBS) concentrations were assessed using enzymatic methods and commercial kits. The DTAC was calculated based on the oxygen radical absorbance capacity of each food (except for coffee) reported by US Department of Agriculture. Statistical Analysis was carried out using SPSS Software.
Results: The mean±SD (standard deviation) for age and body mass index (BMI) of the study participants were 43.9 years ±5.9 and had 30.5 kg/m2 ±2.6. The NAFLD patients included higher BMI and female proportion, compared to control group. The NAFLD patients included higher smoking rates, biochemical parameters (TG, TC, HDL-C, LDL-C and FBS) and DTAC scores, compared to control groups. However, patients with NAFLD included lower HDL levels and physical activities, compared to control group. The highest tertile of DTAC showed lower risks of NAFLD, compared to the lowest tertile. This association was significant after controlling for potential confounders (p for trend <0.001).
Conclusions: Findings suggest that promotion of naturally increased antioxidant capacities may help prevent development of NAFLD.
Keywords: Dietary total antioxidant capacity, Obesity, Nonalcoholic fatty liver disease
Full-Text [PDF 643 kb]   (133 Downloads)    
Protocol Study: Research | Subject: nutrition
Received: 2020/04/12 | Accepted: 2020/05/27 | Published: 2020/08/10
1. Petaja EM, Yki-Jarvinen H. Definitions of normal liver fat and the association of insulin sensitivity with acquired and genetic NAFLD-a systematic review. International journal of molecular sciences. 2016;17(5):633. [DOI:10.3390/ijms17050633]
2. Than NN, Newsome PN. A concise review of non-alcoholic fatty liver disease. Atherosclerosis. 2015;239(1):192-202. [DOI:10.1016/j.atherosclerosis.2015.01.001]
3. Anderson EL, Howe LD, Jones HE, Higgins JP, Lawlor DA, Fraser A. The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis. PloS one. 2015;10(10). [DOI:10.1371/journal.pone.0140908]
4. Moghaddasifar I, Lankarani K, Moosazadeh M, Afshari M, Ghaemi A, Aliramezany M, et al. Prevalence of non-alcoholic fatty liver disease and its related factors in Iran. International journal of organ transplantation medicine. 2016;7(3):149.
5. Ashraf N, Sheikh T. Endoplasmic reticulum stress and oxidative stress in the pathogenesis of non-alcoholic fatty liver disease. Free radical research. 2015;49(12):1405-18. [DOI:10.3109/10715762.2015.1078461]
6. Cichoż-Lach H, Michalak A. Oxidative stress as a crucial factor in liver diseases. World journal of gastroenterology: WJG. 2014;20(25):8082. [DOI:10.3748/wjg.v20.i25.8082]
7. Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status and disease: is the total antioxidant capacity the right tool? Redox report. 2004;9(3):145-52. [DOI:10.1179/135100004225004814]
8. Meydani M. Dietary antioxidants modulation of aging and immune-endothelial cell interaction. Mechanisms of ageing and development. 1999;111(2-3):123-32. [DOI:10.1016/S0047-6374(99)00067-6]
9. Ivancovsky-Wajcman D, Fliss-Isakov N, Salomone F, Webb M, Shibolet O, Kariv R, et al. Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease. Digestive and Liver Disease. 2019;51(12):1698-705. [DOI:10.1016/j.dld.2019.06.005]
10. Mancini FR, Affret A, Dow C, Balkau B, Bonnet F, Boutron-Ruault M-C, et al. Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort. Diabetologia. 2018;61(2):308-16. [DOI:10.1007/s00125-017-4489-7]
11. Hermsdorff HHM, Puchau B, Volp ACP, Barbosa KB, Bressan J, Zulet MÁ, et al. Dietary total antioxidant capacity is inversely related to central adiposity as well as to metabolic and oxidative stress markers in healthy young adults. Nutrition & metabolism. 2011;8(1):59. [DOI:10.1186/1743-7075-8-59]
12. Koch TR, Yuan L-X, Stryker SJ, Ratliff P, Telford GL, Opara EC. Total antioxidant capacity of colon in patients with chronic ulcerative colitis. Digestive diseases and sciences. 2000;45(9):1814-9. [DOI:10.1023/A:1005517824877]
13. Villaverde P, Lajous M, MacDonald C-J, Fagherazzi G, Bonnet F, Boutron-Ruault M-C. High dietary total antioxidant capacity is associated with a reduced risk of hypertension in French women. Nutrition journal. 2019;18(1):31. [DOI:10.1186/s12937-019-0456-0]
14. Rautiainen S, Levitan EB, Orsini N, Åkesson A, Morgenstern R, Mittleman MA, et al. Total antioxidant capacity from diet and risk of myocardial infarction: a prospective cohort of women. The American journal of medicine. 2012;125(10):974-80. [DOI:10.1016/j.amjmed.2012.03.008]
15. de Oliveira DG, de Faria Ghetti F, Moreira APB, Hermsdorff HHM, de Oliveira JM, de Castro LEVV. Association between dietary total antioxidant capacity and hepatocellular ballooning in nonalcoholic steatohepatitis: a cross-sectional study. European journal of nutrition. 2019;58(6):2263-70. [DOI:10.1007/s00394-018-1776-0]
16. Ahmad S, Harris T, Limb E, Kerry S, Victor C, Ekelund U, et al. Evaluation of reliability and validity of the General Practice Physical Activity Questionnaire (GPPAQ) in 60-74 year old primary care patients. 2015;16(1):113. [DOI:10.1186/s12875-015-0324-8]
17. Shannon A, Alkhouri N, Carter-Kent C, Monti L, Devito R, Lopez R, et al. Ultrasonographic quantitative estimation of hepatic steatosis in children with nonalcoholic fatty liver disease (NAFLD). Journal of pediatric gastroenterology and nutrition. 2011;53(2):190. [DOI:10.1097/MPG.0b013e31821b4b61]
18. Azadbakht L, Esmaillzadeh A. Red meat intake is associated with metabolic syndrome and the plasma C-reactive protein concentration in women. The Journal of nutrition. 2009;139(2):335-9. [DOI:10.3945/jn.108.096297]
19. Haytowitz DB, Bhagwat S. USDA database for the oxygen radical absorbance capacity (ORAC) of selected foods, Release 2. US Department of Agriculture. 2010:10-48.
20. Sotoudeh G, Abshirini M, Bagheri F, Siassi F, Koohdani F, Aslany Z. Higher dietary total antioxidant capacity is inversely related to prediabetes: a case-control study. Nutrition. 2018;46:20-5. [DOI:10.1016/j.nut.2017.08.005]
21. Vece MM, Agnoli C, Grioni S, Sieri S, Pala V, Pellegrini N, et al. Dietary total antioxidant capacity and colorectal cancer in the Italian EPIC cohort. PLoS One. 2015;10(11). [DOI:10.1371/journal.pone.0142995]
22. Georgoulis M, Fragopoulou E, Kontogianni MD, Margariti A, Boulamatsi O, Detopoulou P, et al. Blood redox status is associated with the likelihood of nonalcoholic fatty liver disease irrespectively of diet's total antioxidant capacity. Nutrition Research. 2015;35(1):41-8. [DOI:10.1016/j.nutres.2014.11.004]
23. Hekmatdoost A, Shamsipour A, Meibodi M, Gheibizadeh N, Eslamparast T, Poustchi H. Adherence to the dietary approaches to stop hypertension (DASH) and risk of nonalcoholic fatty liver disease. International journal of food sciences and nutrition. 2016;67(8):1024-9. [DOI:10.1080/09637486.2016.1210101]
24. Xiao M-L, Lin J-S, Li Y-H, Liu M, Deng Y-Y, Wang C-Y, et al. Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is associated with lower presence of non-alcoholic fatty liver disease in middle-aged and elderly adults. Public Health Nutrition. 2019:1-9. [DOI:10.1017/S1368980019002568]
25. Liese AD, Nichols M, Sun X, D'Agostino RB, Haffner SM. Adherence to the DASH Diet is inversely associated with incidence of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes care. 2009;32(8):1434-6. [DOI:10.2337/dc09-0228]
26. Chen Y-P, Lu F-B, Hu Y-B, Xu L-M, Zheng M-H, Hu E-D. A systematic review and a dose-response meta-analysis of coffee dose and nonalcoholic fatty liver disease. Clinical Nutrition. 2019;38(6):2552-7. [DOI:10.1016/j.clnu.2018.11.030]
27. Guo H, Zhong R, Liu Y, Jiang X, Tang X, Li Z, et al. Effects of bayberry juice on inflammatory and apoptotic markers in young adults with features of non-alcoholic fatty liver disease. Nutrition. 2014;30(2):198-203. [DOI:10.1016/j.nut.2013.07.023]
28. Malhi H, Loomba R. dark chocolate may improve NAFLD and metabolic syndrome by reducing oxidative stress. Alimentary pharmacology & therapeutics. 2016;44(5):533. [DOI:10.1111/apt.13716]
29. Emamat H, Foroughi F, Eini-Zinab H, Taghizadeh M, Rismanchi M, Hekmatdoost A. The effects of onion consumption on treatment of metabolic, histologic, and inflammatory features of nonalcoholic fatty liver disease. Journal of Diabetes & Metabolic Disorders. 2015;15(1):25. [DOI:10.1186/s40200-016-0248-4]
30. Nikkhah-Bodaghi M, Ghanavati M, Hekmatdoost A. Polyphenol intakes and risk of impaired lipid profile, elevated hepatic enzymes and nonalcoholic fatty liver disease. Nutrition & Food Science. 2019. [DOI:10.1108/NFS-12-2018-0338]
31. García-Alonso F, González-Barrio R, Martín-Pozuelo G, Hidalgo N, Navarro-González I, Masuero D, et al. A study of the prebiotic-like effects of tomato juice consumption in rats with diet-induced non-alcoholic fatty liver disease (NAFLD). Food & function. 2017;8(10):3542-52. [DOI:10.1039/C7FO00393E]
32. Sawangjit R, Chongmelaxme B, Phisalprapa P, Saokaew S, Thakkinstian A, Kowdley KV, et al. Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD): A PRISMA-compliant systematic review and network meta-analysis. Medicine. 2016;95(32). [DOI:10.1097/MD.0000000000004529]
33. Narasimhan S, Gokulakrishnan K, Sampathkumar R, Farooq S, Ravikumar R, Mohan V, et al. Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes. Clinical biochemistry. 2010;43(10-11):815-21. [DOI:10.1016/j.clinbiochem.2010.04.003]
34. Liu W, Baker SS, D Baker R, Zhu L. Antioxidant mechanisms in nonalcoholic fatty liver disease. Current drug targets. 2015;16(12):1301-14. [DOI:10.2174/1389450116666150427155342]
35. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology. 2007;39(1):44-84. [DOI:10.1016/j.biocel.2006.07.001]
36. Mouzaki M, Allard JP. The role of nutrients in the development, progression, and treatment of nonalcoholic fatty liver disease. Journal of clinical gastroenterology. 2012;46(6):457-67. [DOI:10.1097/MCG.0b013e31824cf51e]
37. Dreher ML. Dietary Patterns, Foods, Nutrients and Phytochemicals in Non-Alcoholic Fatty Liver Disease. Dietary Patterns and Whole Plant Foods in Aging and Disease: Springer; 2018. p. 291-311. [DOI:10.1007/978-3-319-59180-3_10]
38. Jakobsen MU, Berentzen T, Sørensen T, Overvad K. Abdominal obesity and fatty liver. Epidemiologic reviews. 2007;29(1):77-87. [DOI:10.1093/epirev/mxm002]
39. Barnard ND, Scialli AR, Turner-McGrievy G, Lanou AJ, Glass J. The effects of a low-fat, plant-based dietary intervention on body weight, metabolism, and insulin sensitivity. The American journal of medicine. 2005;118(9):991-7. [DOI:10.1016/j.amjmed.2005.03.039]
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sohouli M, Fatahi S. Associations between Dietary Total Antioxidant Capacity and Risk of Nonalcoholic Fatty Liver Disease (NAFLD) in Adults: A Case-Control Study. Nutr Food Sci Res. 2020; 7 (3) :1-7
URL: http://nfsr.sbmu.ac.ir/article-1-402-en.html

Volume 7, Issue 3 (Jul-Sep 2020) Back to browse issues page
Nutrition and Food Sciences Research
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4227