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The Simultaneous effect of Aerobic Training and Berberine Chloride on Plasma Blood Glucose, IL-6 and TNF-α in Type 1 Diabetic male wistar rats
Javad Ramezani , Mohammad Ali Azarbayjani , Maghsoud Peeri
Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (34 Views)
Background and Objectives: Aerobic Training and Berberine chloride have both anti-oxidant and anti-inflammatory properties. The purpose of this study was to investigate the effect Simultaneously of Aerobic Training and Berberine chloride on Plasma Blood Glucose, IL-6 and TNF-α in Type 1 Diabetic male rats.
Materials and Methods: In this experimental study, 64 male Wistar rats were randomly divided into eight groups(n=8), including Healthy control, Diabetic control, Diabetic-Berberine(15,30mg/kg), Diabetic-Training, Diabetic-Training-Berberine(15,30mg/kg) and Healthy-Training. Diabetes was induced by single intraperitoneal injection of STZ of 60mg/kg b.w. The Training schedule included running on the treadmill for six weeks, five sessions a week, and Daily ingestion of Berberine by gavage. IL-6 and TNF-α values were measured by ELISA method.
Results: The results showed that the glucose concentration in diabetic groups receiving Aerobic Training and Berberine simultaneously was significantly lower than diabetic control group(P <0.05). Plasma interleukin-6 in the diabetic control group was not significantly different compare to the healthy control(P> 0.05). However, in diabetic groups receiving both variables simultaneously, interleukin-6 had a significant increase compared to the diabetic control group(P <0/05).The amount of TNF-α in diabetic control was significantly higher than healthy control(P <0.05). The level of this variable was significantly reduced in all treatment groups compared to diabetic control(P <0.05).
Conclusion: The combined effects of these two variables (Berberine and Aerobic Training) on blood glucose, interleukin-6 and TNF- α are more evident than their individual effects. Also, a Dosage of 30mg/kg of Berberine chloride has a greater effect than the Dosage of 15mg/kg on these factors.
Keywords: Type 1 Diabetes, Aerobic Training, Berberine Chloride, IL-6, TNF-α
     
Type of Study: Research | Subject: Special
Received: 2018/09/17 | Accepted: 2018/12/16
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