[Home ] [Archive]    
:: Main :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 4, Issue 4 (Oct-Dec 2017) ::
Nutr Food Sci Res 2017, 4(4): 9-13 Back to browse issues page
Analysis of CRP, Vitamin D and Metabolic Factors in Non-obese Patients with Polycystic Ovary Syndrome: a Cross Sectional Study in Imam Khomeini Hospital, Ahvaz
Omid Nikpayam , Golbon Sohrab
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (220 Views)

Background and Objectives: The polycystic ovary syndrome (PCOS) is one of the most common diseases diagnosed in women of childbearing age which is associated with increased risk of metabolic complications, including cardiovascular disease. Increasing C-reactive protein (CRP) as an inflammatory factor is common in these patients. In addition, vitamin D deficiency is quite common among females with PCOS. The aim of this study is to determine the relationship of CRP levels with vitamin D and metabolic factors in Non-obese Patients with PCOS.
Materials and Methods: This experimental study was done on 100 non-obese 20-40 years old females (BMI<30) who were diagnosed with PCOS. Based on CRP levels, the females are categorized in two groups (normal CRP<0.8 mg/dl). The serum levels of HOMA-IRC, FBS, HDL-C, LDL-CHL, Vitamin D and CRP of participants in the study were measured. Then, collected data was analyzed through the SPSS Software (version. 23). In all analysis, the p-value is presumed to be less than 0.05.
Results: The mean age of patients was 27.11±6.25. Patients in high CRP group, had significantly lower levels of HDL-C and higher Triglyceride (TG) compared to controls. In addition, the increase in CRP was associated with vitamin D deficiency. This was while no significant difference between the two groups of patients were observed in terms of insulin resistance.
Conclusions: The findings of present study suggest that higher CRP levels are positively correlated with vitamin D and HDL-C deficiency as well as an increased TG levels in non-obese females with PCOS. These findings have significant implications for the understanding of how vitamin D deficiency can contribute to inflammatory and metabolic responses in patients with PCOS. A future study could assess the long-term implications of vitamin D supplementation on inflammation and metabolic outcome of patients with PCOS.

Keywords: PCOS, Vitamin D, CRP, Inflammation, Metabolic Factors
Full-Text [PDF 65 kb]   (87 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/06/20 | Accepted: 2017/10/14 | Published: 2017/10/14
References
1. 1. Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005; 90(4): 1929-35.
2. 2. Delitala AP, Capobianco G, Delitala G, Cherchi PL, Dessole S. Polycystic ovary syndrome, adipose tissue and metabolic syndrome. Arch Gynecol Obstet. 2017; 296(3): 405-419.
3. 3. Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber T, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol. 2009;161(4):575-82.
4. 4. Boulman, N et al. Increased C-reactive protein levels in the polycystic ovary syndrome: a marker of cardiovascular disease. J Clin Endocrinol Metab. 2008; 89(5): 2160-5.
5. 5. Condorelli RA, Calogero AE, Di Mauro M, La Vignera S. PCOS and diabetes mellitus: from insulin resistance to altered beta pancreatic function, a link in evolution. Gynecological endocrinology: Gynecol Endocrinol. 2017:1-3
6. 6. DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertil Steril. 2008; 83(5): 1454-60.
7. 7. Dumitrescu R, Mehedintu C, Briceag I, Purcarea V, Hudita D. The polycystic ovary syndrome: An update on metabolic and hormonal mechanisms.J Med Life . 2008;8(2): 142.
8. 8. González, F.Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction. Steroids. 2012; 77(4): 300-5.
9. 9. Holick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. Am J Clin Nutr. 2008; 87(4): 1080S-6S.
10. 10. Li HWR, Brereton RE, Anderson RA, Wallace AM, Ho CK. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism. 2011;60(10):1475-81.
11. 11. Auwerx J, Bouillon R, Kesteloot H. Relation between 25-hydroxyvitamin D3, apolipoprotein AI, and high density lipoprotein cholesterol. Arterioscler Thromb Vasc Biol. 1992;12(6):671-4.
12. 12. Xiong, Y-l., Liang, X-y., Yang, X., Li, Y & Wei, L-n. Low-grade chronic inflammation in the peripheral blood and ovaries of women with polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol. 2011; 159(1): 148-50.
13. 13. Galluzzo A, Amato MC, Giordano C. Insulin resistance and polycystic ovary syndrome. Nutr Metab Cardiovasc Dis. 2008;18(7):511-8.
14. 14. Legro RS, Castracane VD, Kauffman RP. Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet Gynecol Surv. 2004;59(2):141-54.
15. 15. Gunning MN, Fauser B. Are women with polycystic ovary syndrome at increased cardiovascular disease risk later in life? Climacteric. 2017; 20(3):222-7.
16. 16. Dahlgren E, Janson P, Johansson S, Lapidus L, Oden A. Polycystic ovary syndrome and risk for myocardial infarction: evaluated from a risk factor model based on a prospective population study of women. Acta Obstet Gynecol Scand. 1992;71(8):599-604.
17. 17. Morin G, Orlando V, Crites KS-M, Patey N, Mailhot G. Vitamin D attenuates inflammation in CFTR Knockdown Intestinal epithelial cells but has no effect in cells with intact CTFR. Am J Physiol Gastrointest Liver Physiol. ajpgi. 00060.2016;310 (8):539-549
18. 18. Ngo DT, Chan WP, Rajendran S, Heresztyn T, Amarasekera A, Sverdlov AL et al. Determinants of insulin responsiveness in young women: impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide. 2011; 25(3):326-30.
19. 19. Orio Jr F, Palomba S, Spinelli L. The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study. J Clin Endocrinol Metab.2004; 89(8): 3696-701.
20. 20. Moller D E. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol. Metab. 2000; 11: 212-217. 21. Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 2003. 100:7265-7270.
21. 22. Rashid S, Watanabe T, Sakaue T, Lewis GF. Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: The combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity. Clin Biochem.2003; 36(6): 421-9.
22. 23. H J, He S, Liu K, Wang Y, Shi D, Chen X. The TG/HDL-C ratio might be a surrogate for insulin resistance in Chinese non-obese women. Int J Endocrinol. 2014; 47 (16): 355-371
23. 24. Couto Alves A, Valcarcel B, Makinen VP, Morin-Papunen L, Sebert S, Kangas AJ, et al. Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity. Int J Obes (Lond) . 2017; 41(9): 1331–1340. 
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nikpayam O, Sohrab G. Analysis of CRP, Vitamin D and Metabolic Factors in Non-obese Patients with Polycystic Ovary Syndrome: a Cross Sectional Study in Imam Khomeini Hospital, Ahvaz. Nutr Food Sci Res. 2017; 4 (4) :9-13
URL: http://nfsr.sbmu.ac.ir/article-1-237-en.html
Volume 4, Issue 4 (Oct-Dec 2017) Back to browse issues page
Nutrition and Food Sciences Research
Persian site map - English site map - Created in 0.051 seconds with 815 queries by yektaweb 3535