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Assessing Effects of Serum 25-Hydroxyvitamin D Levels on Anxiety and Depression in Patients with Colorectal Adenocarcinoma
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Reyhaneh Entezari    , Vahid Pouresmaeil * , Amir Amirabadi , Vahid Saadatian , Payam Izadpanahi |
| Department of Biochemistry, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran. & Innovative Medical Research Center, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran. , vahidpouresmail@yahoo.fr |
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Abstract: (18 Views) |
Background and Objectives: In colorectal cancer patients experiencing depression and anxiety, vitamin D supplementation may boost mood by rectifying serum 25(OH)D levels. This study assessed the potential for vitamin D to alleviate symptoms of depression and anxiety in colorectal cancer patients with insufficient clinical evidence available.
Materials and Methods: In this study, 46 colorectal adenocarcinoma patients were included based on specific inclusion criteria. Serum 25(OH)D levels were assessed using enzyme-linked immunosorbent assay and assessed anxiety and depression using Zung's questionnaire at baseline. Based on the baseline serum 25(OH)D levels, patients were categorized into four groups of < 12 ng/ml, 12–20 ng/ml, 20–30 ng/ml and ≥ 30 ng/ml. A standard dose of vitamin D supplementation was administered based on the study protocol. After 12 w, serum 25(OH)D levels, anxiety and depression were assessed and statistical analyses were carried out.
Results: In this clinical trial, 80% of patients (median age, 56.8 y) had inadequate baseline serum 25(OH)D levels (< 30 ng/ml), with 28.3% having depressive symptoms (Zung SDS score > 50) and 37% showing anxiety symptoms (Zung SAS score ≥ 40). The average serum 25(OH)D level increased from 25.4 ng/ml before the intervention to 34.8 ng/ml post-intervention. Significant differences were reported in serum 25(OH)D levels before and after the intervention (p = 0.0001). Additionally, significant decreases were reported in the mean scores for anxiety (p = 0.021) and depression (p = 0.015) after the intervention. Changes in serum 25(OH)D levels were significant and inversely correlated with changes in depression (p = 0.0186) and anxiety (p = 0.0099) scores.
Conclusions: Vitamin D supplementation may significantly improve depression and anxiety symptoms in colorectal adenocarcinoma patients. |
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| Keywords: 25-Hydroxyvitamin D, Colorectal cancer, Depression, Anxiety, Clinical trial |
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Full-Text [PDF 688 kb]
(9 Downloads)
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Article type: Research |
Subject:
Nutrition
Received: 2024/09/1 | Accepted: 2024/09/9
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- In general, 37% of colorectal cancer patients had anxiety scores of 50% or greater before the intervention. Significant differences were reported between the mean scores before and after the intervention.
- Moreover, 28.3% of colorectal cancer patients had depression scores greater than 50 before the intervention. Significant difference were seen between the mean scores before and after the intervention.
- Changes in serum 25(OH)D levels were significantly correlated with changes in depression and anxiety scores.
- Vitamin D supplementation decreased anxiety and depression in patients with colorectal adenocarcinoma.
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