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Evaluating the Impact of Vitamin D Supplementation on Serum Leptin Levels: A Meta-Analysis of Randomized Controlled Trials
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Bahareh Nikooyeh *    , Mohammad Esmail Motlagh , Tirang Neyestani |
| Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran , nikooyeh11024@yahoo.com |
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Abstract: (360 Views) |
Background and Objectives: Vitamin D, crucial for bone health and calcium homeostasis, also impacts metabolic processes and endocrine functions. It may influence leptin, a key hormone regulating energy balance. This meta-analysis evaluates the effect of vitamin D supplementation on serum leptin concentrations, addressing inconsistencies and exploring its potential role in metabolic health.
Materials and Methods: This review examined supplementation with vitamin D, alone or with calcium, as an intervention for its effects on serum leptin concentrations. Following PRISMA guidelines, a comprehensive search of electronic databases up to March 2024 identified eligible trials. Eleven randomized clinical trials were included, assessing vitamin D supplementation versus placebo or control. The meta-analysis, registered in PROSPERO (www.crd.york.ac.uk/ PROSPERO/ CRD42020177472), used STATA for statistical analysis, with outcomes reported as mean differences (MD) and 95% confidence intervals (CIs).
Results: Initially, 503 studies were identified, with 366 excluded after screening. Ultimately, 11 studies with 819 participants were included. Trials varied in vitamin D dosage, frequency, and whether calcium was included. Pooled analysis found no significant effect of vitamin D on leptin concentrations (MD: -0.13, 95% CI -1.12 to 0.87). Subgroup analyses showed no differences based on intervention duration or calcium inclusion.
Conclusions: Our meta-analysis demonstrated that vitamin D supplementation does not significantly affect serum leptin levels, adding to the existing evidence on vitamin D metabolic roles. Further research is crucial to unravel the interaction between vitamin D and adipokines like leptin, given widespread vitamin D deficiency and its metabolic implications. |
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| Keywords: Vitamin D, Leptin, Meta-analysis |
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Full-Text [PDF 752 kb]
(149 Downloads)
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Article type: Review |
Subject:
Nutrition
Received: 2024/07/4 | Accepted: 2024/07/9 | Published: 2024/08/12
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Highlights
- Vitamin D supplementation does not have a statistically significant effect on leptin concentrations.
- Subgroup analyses did not reveal any significant differences in leptin response.
- Sensitivity analyses confirmed the stability of our primary findings.
- Vitamin D supplementation alone may not be sufficient to modulate leptin levels in diverse populations.
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