[Home ] [Archive]    
:: Main :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 8, Issue 2 (Apr-Jun 2021) ::
Nutr Food Sci Res 2021, 8(2): 51-56 Back to browse issues page
The Effect of Bisphenol A on the Histological Parameters of Male Rat Prefrontal Area
Farid Habibi, Shabnam Movassaghi , Amirhossein Saeinia , Mohammad Mahdi Nazarnejad , Shabnam Abdi
Department of Anatomical Sciences &Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Abstract:   (285 Views)
Background and Objectives: Bisphenol-A (BPA) is a substance used in epoxy resin monomers and polycarbonate plastics. This research focuses on the effect of Bisphenol A on histology alterations in prefrontal cortex (PFC) of rats.
Materials and Methods: Thirty male rats were divided into 3 groups: A control group, a placebo group received distilled water intra peritoneal and the experiment group received 1.0µg/kg BPA intra peritoneal for 14 days. After 2 weeks, rat’s brains were enucleated, sequenced in 10µm widths and HE stained for histological examinations. Neural and neuroglia cells were counted and rats’ PFC volume was measured using stereological methods.
Results: Our results showed statistically significant decreases in PFC volume and neural cell count in the experiment group in comparison to both placebo and control groups. Also, results showed statistically significant increases in glial cell count in the experiment group in comparison to other groups.
Conclusions: This research showed that BPA has negative and pathological effects on neural cells and PFC in rats
Keywords: Bisphenol A, Prefrontal cortex, Rats
Full-Text [PDF 728 kb]   (62 Downloads)    
Article type: Research | Subject: Food Science
Received: 2020/05/22 | Accepted: 2020/12/30 | Published: 2021/04/7
1. Mandel ND, Gamboa-Loira B, Cebrián ME, Mérida-Ortega Á, López-Carrillo L. Challenges to regulate products containing bisphenol A: Implications for policy. salud pública de méxico. 2019;61(5, sep-oct):692-7. [DOI:10.21149/10411]
2. Kimber I. Bisphenol A and immunotoxic potential: A commentary. Regulatory Toxicology and Pharmacology. 2017;90:358-63. [DOI:10.1016/j.yrtph.2017.08.022]
3. Cabado AG, Aldea S, Porro C, Ojea G, Lago J, Sobrado C, et al. Migration of BADGE (bisphenol A diglycidyl-ether) and BFDGE (bisphenol F diglycidyl-ether) in canned seafood. Food and chemical toxicology. 2008;46(5):1674-80. [DOI:10.1016/j.fct.2008.01.006]
4. Wazir U, Mokbel K. Bisphenol A: A concise review of literature and a discussion of health and regulatory implications. in vivo. 2019;33(5):1421-3. [DOI:10.21873/invivo.11619]
5. Akash MSH, Sabir S, Rehman K. Bisphenol A-induced metabolic disorders: From exposure to mechanism of action. Environmental Toxicology and Pharmacology. 2020;77:103373. [DOI:10.1016/j.etap.2020.103373]
6. Valentino R, D'Esposito V, Ariemma F, Cimmino I, Beguinot F, Formisano P. Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population? Journal of endocrinological investigation. 2016;39(3):259-63. [DOI:10.1007/s40618-015-0336-1]
7. Vahedi M, Saeedi A, Poorbaghi SL, Sepehrimanesh M, Fattahi M. Metabolic and endocrine effects of bisphenol A exposure in market seller women with polycystic ovary syndrome. Environmental Science and Pollution Research. 2016;23(23):23546-50. [DOI:10.1007/s11356-016-7573-5]
8. Radwan M, Wielgomas B, Dziewirska E, Radwan P, Kałużny P, Klimowska A, et al. Urinary bisphenol A levels and male fertility. American journal of men's health. 2018;12(6):2144-51. [DOI:10.1177/1557988318799163]
9. Murata M, Kang J-H. Bisphenol A (BPA) and cell signaling pathways. Biotechnology Advances. 2018;36(1):311-27. [DOI:10.1016/j.biotechadv.2017.12.002]
10. Koike E, Yanagisawa R, Win-Shwe T-T, Takano H. Exposure to low-dose bisphenol A during the juvenile period of development disrupts the immune system and aggravates allergic airway inflammation in mice. International journal of immunopathology and pharmacology. 2018;32: 2058738418774897. [DOI:10.1177/2058738418774897]
11. Fujiwara Y, Miyazaki W, Koibuchi N, Katoh T. The effects of low-dose bisphenol A and bisphenol F on neural differentiation of a fetal brain-derived neural progenitor cell line. Frontiers in Endocrinology. 2018;9:24. [DOI:10.3389/fendo.2018.00024]
12. Heidbreder CA, Groenewegen HJ. The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neuroscience & Biobehavioral Reviews. 2003;27(6):555-79. [DOI:10.1016/j.neubiorev.2003.09.003]
13. Carlén M. What constitutes the prefrontal cortex? Science. 2017;358(6362):478-82. [DOI:10.1126/science.aan8868]
14. Gundersen H, BENDTSEN TF, KORBO L, MARCUSSEN N, Møller A, Nielsen K, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. Apmis. 1988;96(1‐6):379-94. [DOI:10.1111/j.1699-0463.1988.tb05320.x]
15. Elsworth JD, Jentsch JD, VandeVoort CA, Roth RH, Redmond Jr DE, Leranth C. Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates. Neurotoxicology. 2013;35:113-20. [DOI:10.1016/j.neuro.2013.01.001]
16. Eilam-Stock T, Serrano P, Frankfurt M, Luine V. Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats. Behavioral neuroscience. 2012;126(1):175. [DOI:10.1037/a0025959]
17. Asgari Hasanluyi E, Banan Khojasteh M, Fazeli M, Hatami H. Investigating the Neurotoxicity of Bisphenol A on Spatial Learning and Memory in Male Rats. Journal of Mazandaran University of Medical Sciences. 2016;26(140):192-6.
18. Kim ME, Park HR, Gong EJ, Choi SY, Kim HS, Lee J. Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory. Food and chemical toxicology. 2011;49(12):3383-9. [DOI:10.1016/j.fct.2011.09.017]
19. Bowman RE, Luine V, Weinstein SD, Khandaker H, DeWolf S, Frankfurt M. Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats. Hormones and behavior. 2015;69:89-97. [DOI:10.1016/j.yhbeh.2014.12.007]
20. Rahimi O, Farokhi F, Banan Khojasteh SM. The effect of bisphenol A on liver tissue structure and liver enzymes. Qom University of Medical Sciences Journal. 2016;9(12):1-7.
21. Bansal A, Rashid C, Xin F, Li C, Polyak E, Duemler A, et al. Sex-and dose-specific effects of maternal bisphenol A exposure on pancreatic islets of first-and second-generation adult mice offspring. Environmental health perspectives. 2017;125(9):097022. [DOI:10.1289/EHP1674]
22. Wise LM, Sadowski RN, Kim T, Willing J, Juraska JM. Long-term effects of adolescent exposure to bisphenol A on neuron and glia number in the rat prefrontal cortex: differences between the sexes and cell type. Neurotoxicology. 2016;53:186-92. [DOI:10.1016/j.neuro.2016.01.011]
23. Castro B, Sánchez P, Torres JM, Ortega E. Bisphenol A, bisphenol F and bisphenol S affect differently 5α-reductase expression and dopamine-serotonin systems in the prefrontal cortex of juvenile female rats. Environmental research. 2015;142:281-7. [DOI:10.1016/j.envres.2015.07.001]
24. Taherianfard M, Taci A. Effects of Bisphenol A and Learning on the Distribution of GABA Aα1 Receptors in the Rat Hippocampus and Prefrontal Cortex. Neurophysiology. 2015;47(1):23-9. [DOI:10.1007/s11062-015-9492-3]
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Habibi F, Movassaghi S, saeinia A, Nazarnejad M M, Abdi S. The Effect of Bisphenol A on the Histological Parameters of Male Rat Prefrontal Area. Nutr Food Sci Res. 2021; 8 (2) :51-56
URL: http://nfsr.sbmu.ac.ir/article-1-411-en.html

Volume 8, Issue 2 (Apr-Jun 2021) Back to browse issues page
Nutrition and Food Sciences Research
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4319