en Nutrition Nutrition Study Protocol Study Protocol <span style="font-size:10pt"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b>Background and objectives: </b>Breast cancer is the most common type of cancer and the leading cause of death in women worldwide. Early detection of breast cancer by measuring metabolites that can be easily detected through blood tests will significantly help in time treatment, prevent cancer progression, and reduce the risk of death in breast cancer patients. One of the constant metabolic characteristics of cancer is lipidomic remodeling, which includes changes in fatty acid transport, lipogenesis, lipid storage, and beta-oxidation to supply energy. This review aims to compare lipid changes between women with and without breast cancer.</span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b>Materials and methods: </b>The systematic review will search and summarize data on observational studies from Medline/PubMed, Scopus, Embase, and Web of Science databases and grey literature published between January 2000 and January 2025. Keywords related to &#39;breast cancer&#39; and &#39;lipidomic&#39; will be used to retrieve relevant documents.<b> </b>The<b> </b>PECOS model will be used to include eligible studies. The protocol of this systematic review follows the PRISMA-P statement.</span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b>Results and conclusion: </b>This systematic review will help summarize the existing evidence about the use of blood lipids in breast cancer diagnosis and prognosis and recognize the current gaps in research to design further high-quality studies with the ultimate goal of easy and early detection of breast cancer.</span></span></span> Blood lipids, Breast cancer, Lipidomic, Protocol, Systematic review 1 5 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-730-4&slc_lang=en&sid=1 Zahra Hosseinpour Hosseinpour_z@yahoo.com 10031947532846006879 10031947532846006879 No Skin Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran Mahsa Alem m.alem@urmia.ac.ir 10031947532846006880 10031947532846006880 No Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Elham Anari anari.elham@yahoo.com 10031947532846006881 10031947532846006881 No Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran Razieh Anari Raziehanari85@yahoo.com 10031947532846006882 10031947532846006882 Yes Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University‏ ‏of Medical ‎Sciences, Ahvaz 61375-15794, Iran