Nutrition And Food In Health And Disease

en Assessing Effects of Serum 25-Hydroxyvitamin D Levels on Anxiety and Depression in Patients with Colorectal Adenocarcinoma Nutrition Nutrition پژوهشي Research Background and Objectives: In colorectal cancer patients experiencing depression and anxiety, vitamin D supplementation may boost mood by rectifying serum 25(OH)D levels. This study assessed the potential for vitamin D to alleviate symptoms of depression and anxiety in colorectal cancer patients with insufficient clinical evidence available. Materials and Methods: In this study, 46 colorectal adenocarcinoma patients were included based on specific inclusion criteria. Serum 25(OH)D levels were assessed using enzyme-linked immunosorbent assay and assessed anxiety and depression using Zung's questionnaire at baseline. Based on the baseline serum 25(OH)D levels, patients were categorized into four groups of < 12 ng/ml, 12–20 ng/ml, 20–30 ng/ml and ≥ 30 ng/ml. A standard dose of vitamin D supplementation was administered based on the study protocol. After 12 w, serum 25(OH)D levels, anxiety and depression were assessed and statistical analyses were carried out. Results: In this clinical trial, 80% of patients (median age, 56.8 y) had inadequate baseline serum 25(OH)D levels (< 30 ng/ml), with 28.3% having depressive symptoms (Zung SDS score > 50) and 37% showing anxiety symptoms (Zung SAS score ≥ 40). The average serum 25(OH)D level increased from 25.4 ng/ml before the intervention to 34.8 ng/ml post-intervention. Significant differences were reported in serum 25(OH)D levels before and after the intervention (p = 0.0001). Additionally, significant decreases were reported in the mean scores for anxiety (p = 0.021) and depression (p = 0.015) after the intervention. Changes in serum 25(OH)D levels were significant and inversely correlated with changes in depression (p = 0.0186) and anxiety (p = 0.0099) scores. Conclusions: Vitamin D supplementation may significantly improve depression and anxiety symptoms in colorectal adenocarcinoma patients. 25-Hydroxyvitamin D, Colorectal cancer, Depression, Anxiety, Clinical trial 11 21 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-1135-1&slc_lang=en&sid=1 Reyhaneh Entezari r.entezariheravi7831@iau.ir 10031947532846006704 0009-0008-7023-3375 No Student Research Committee, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran. Vahid Pouresmaeil vahidpouresmail@yahoo.fr 10031947532846006705 10031947532846006705 Yes Department of Biochemistry, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran. Amir Amirabadi amirabadi1980@yahoo.com 10031947532846006706 10031947532846006706 No Department of Internal Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad university, Mashhad, Iran. Vahid Saadatian saadatian1872@gmail.com 10031947532846006707 10031947532846006707 No Department of Psychiatry, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad university, Mashhad, Iran. Payam Izadpanahi dr.izadpanahi@gmail.com 10031947532846006708 10031947532846006708 No Reza Radiation Oncology Center, Mashhad, Iran.