Nutrition And Food In Health And Disease

en Combination Therapy of Flaxseed and Hesperidin Enhances the Effectiveness of Lifestyle Modification in Metabolic Syndrome: A Randomized Controlled Clinical Trial Nutrition Nutrition پژوهشي Research Background and Objectives: Regarding the increasing prevalence of metabolic syndrome (MetS), and its association with non-communicable chronic diseases, providing preventive and therapeutic strategies is a priority. A randomized controlled study was conducted to assess the effects of <a name="_Hlk530993394">combination therapy of milled brown flaxseed and hesperidin</a> during lifestyle intervention on MetS components. Materials and Methods: Forty-eight subjects were randomly assigned to<a name="_Hlk534899067"> receive lifestyle intervention plus combination therapy of brown flaxseed (30 g milled) and hesperidin (two 500 mg capsules) or lifestyle modification alone for 12 weeks. </a>MetS was assessed as a primary endpoint. The trial was registered in clinicaltrial.gov:NCT03737422. Results: Forty-six percent of patients in the flaxseed-hesperidin group experienced more than three MetS factors improvement from baseline to week 12, while only 17% of patients in the control group fall in this category. A comparison of blood pressure changes throughout the study indicated a greater reduction in blood pressure in the intervention group rather than in the control group (-5.66 vs. -1.56 mmHg, P = 0.049). The reduction in plasma glucose (-20.35 vs. -7.46 mg/dL, P = 0.007) and triglyceride (-45.3 vs. -8.39 mg/dL, P = 0.020) in the flaxseed-hesperidin group was significantly more than the control group after 12 weeks of intervention. Conclusions: Our results indicate that co-administration of flaxseed and hesperidin as an adjunct to lifestyle modification program is more effective than lifestyle modification alone in the treatment of metabolic syndrome. Metabolic syndrome, Flaxseed, Hesperidin, Lifestyle modification 11 20 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-849-1&slc_lang=en&sid=1 Azita Hekmatdoost a_hekmat2000@yahoo.com 10031947532846006617 10031947532846006617 No Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Science, Tehran, Iran. Vahideh Behrouz vahideh.behrouz@gmail.com 10031947532846006618 10031947532846006618 No Department of Nutrition, School of Public Health, Kerman University of Medical Sciences, Tehran, Iran. Zahra Yari zahrayari_nut@yahoo.com 10031947532846006619 10031947532846006619 Yes Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.