Nutrition And Food In Health And Disease

en Formulation of Canola Oil with γ-Oryzanol and Evaluation of the Effectiveness of Its Consumption Compared with Unfortified Canola and Sunflower Oils on Certain Cardiometabolic, Oxidative Stress and Immunity Indicators of Adults with Type 2 Diabetes: A Randomized Controlled Clinical Trial Study Protocol Nutrition Nutrition Study Protocol Study Protocol Background and Objectives: Diabetes mellitus is the most common endocrine disorder worldwide. Cardiometabolic risk factors like truncal obesity and unhealthy life style including unhealthy diet contribute to development of type 2 diabetes (T2D) and its complications and attributable deaths. Therefore, modification of the patient's diet and lifestyle is a core of T2D treatment. γ-Oryzanol (ORZ) is a phytochemical found in rice bran oil. An increasing body of evidence has demonstrated health benefits of ORZ including decreasing oxidative stress and insulin resistance.  This study will be conducted to examine possible effects of ORZ-fortified canola oil, as compared with plain canola and sunflower oils, on certain cardiometabolic indicators. Materials and Methods: A total of 90 adult subjects aged 20-65 y with confirmed diagnosis of T2D will randomly be allocated in one to the three groups to receive: (i) ORZ-fortified canola oil (14 mg ORZ/14g); (ii) plain canola oil (without ORZ); and (iii) sunflower oil. All oils will have equal amounts of vitamins D (4.5 μg =180 IU) and A (240 μg =800 IU) per serving, i.e. 14 g. The subjects will be instructed to use only the given oils for cooking during 12 weeks intervention period. Dietary, anthropometric and laboratory evaluations will be done for all participants before and after the intervention. Conclusions: The findings of this study will shed a light to our current knowledge of health aspects of cooking oils and also will input information to our future dietary recommendations to T2D patients and, probably, the general population.   Type 2 diabetes, γ-oryzanol, canola oil, sunflower oil, clinical trial 29 33 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-1-13&slc_lang=en&sid=1 Bahareh Nikooyeh tneyestani@sbmu.ac.ir 10031947532846005889 10031947532846005889 No 1Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Azizollaah Zargaraan 10031947532846005890 10031947532846005890 No Department of Food and Nutrition Policy and Planning Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Science, Shahid Beheshti University of Medical Sciences and Health Services Samira Ebrahimof 10031947532846005900 10031947532846005900 No Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ali Kalayi 10031947532846005891 10031947532846005891 No 1Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Maliheh Zahedirad 10031947532846005892 10031947532846005892 No 1Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hootan Yazdani 10031947532846005893 10031947532846005893 No 1Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Marjan Rismanchi 10031947532846005894 10031947532846005894 No 1Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Taher Karami 10031947532846005895 10031947532846005895 No Department of Research and Development, Kourosh Food Industry, Tehran, Iran Marzieh Khazraei 10031947532846005896 10031947532846005896 No Quality Assurance Unit, Kourosh Food Industry, Tehran, Iran Sahar Saadat 10031947532846005897 10031947532846005897 No Laboratory of Research and Development, Kourosh Food Industry, Eshtehard, Iran Ali Jafarpour 10031947532846005898 10031947532846005898 No Quality Assurance Unit, Kourosh Food Industry, Tehran, Iran Tirang R. Neyestani neytr@yahoo.com 10031947532846005899 10031947532846005899 Yes 1Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran