en Nutrition Nutrition پژوهشي Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="line-height:115%"><span style="tab-stops:409.5pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="line-height:115%">Background and Objectives: </span></span></b>Tuberculosis is one of the major health problems in Bangladesh as well as other regions of the world. The aim of this clinical trial was to investigate combined effects of vitamin C and anti-tuberculosis drugs in tuberculosis patients.<span style="font-size:11.0pt"><span style="line-height:115%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:115%"><span style="tab-stops:409.5pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="line-height:115%">Materials and Methods: </span></span></b>A total of 32 tuberculosis patients were enrolled in the study through random sampling and separated into intervention (vitamin C and anti-tuberculosis drugs) and control (only anti-tuberculosis drugs) groups, where the intervention group was treated with 1000 mg of vitamin C daily in addition to anti-tuberculosis drugs and the control group was treated with only anti-tuberculosis drugs for 28 days. In the second stage, the microbial count of tuberculosis patients was assessed using sputum smear test for control and intervention groups after a 7-d time interval.<span style="font-size:11.0pt"><span style="line-height:115%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:115%"><span style="tab-stops:409.5pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="line-height:115%">Results: </span></span></b>Smear test of the patient first week showed that the microbial loads comparatively decreased compared to the test of the second week using combined treatment of vitamin C and anti-tuberculosis drugs for the intervention group (<i>p</i>=0.034). In contrast, the control group included <i>p</i>=0.000, <i>p</i>=0.341 and <i>p</i>=0.346 for the second, third and fourth-week tests with no significance.<span style="font-size:11.0pt"><span style="line-height:115%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:115%"><span style="tab-stops:409.5pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="line-height:115%">Conclusions: </span></span></b>Combined effects of vitamin C and anti-tuberculosis drugs in TB patients.<span style="font-size:11.0pt"><span style="line-height:115%"></span></span></span></span></span></span></span><br> &nbsp;</div> Tuberculosis, Treatment, Vitamin C, Tuberculosis drugs 3 8 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-1029-1&slc_lang=en&sid=1 Murtaja Reza Linkon murtaja.kus@mbstu.ac.bd 10031947532846005687 10031947532846005687 No Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh Sadia Fahmida Mitu sadiafahmida94@gmail.com 10031947532846005688 10031947532846005688 No Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh Faridul Islam faridul.nutrition@gmail.com 10031947532846005689 10031947532846005689 No Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh Md. Shyfullah dr.saifullah41@gmail.com 10031947532846005690 10031947532846005690 No Department of Medicine, Dhaka Medical College, Dhaka-1000, Bangladesh Prakash Shutradhar prakashsutradhar716@gmail.com 10031947532846005691 10031947532846005691 No Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh Masud Rana smrana141093@gmail.com 10031947532846005692 10031947532846005692 No Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh Rehnova Mostafa Nitu nitu13nitu@gmail.com 10031947532846005693 10031947532846005693 No Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh Sharmin Jalil dr.sharmina41@gmail.com 10031947532846005694 10031947532846005694 No Thana Health Complex, Dhaka, Bangladesh. Abdul Alim alim.food@mbstu.ac.bd 10031947532846005695 10031947532846005695 Yes Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh