en Nutrition Nutrition پژوهشي Research <strong>Background and Objectives: </strong>Diabetes is one of the metabolic diseases with a significant increase rate in recent decades. The aim of this study was to investigate effects of eight weeks of resistance training and consumption of pomegranate juice on Glucagon-like peptide-1(GLP-1), dipeptidyl peptidase 4(DPP-4) and glycemic statuses in women with type 2 diabetes (a randomized controlled trial).<br> <strong>Materials and Methods: </strong>Samples included 40 women with type 2 diabetic aged 45&ndash;55 years, who were randomly selected and divided into four major groups of control (<em>n</em> = 10), resistance training (<em>n</em> = 10), pomegranate juice consumption (<em>n</em> = 10) and resistance training and pomegranate juice consumption (<em>n</em> = 10) groups. Resistance training group and resistance training and pomegranate juice consumption group carried out three resistance training sessions for eight weeks, each week with a maximum intensity of 30%. By the end of the Week 18, groups reached 80% of the maximum repetition. The pomegranate juice group received 100 ml of pomegranate juice every day. Analysis of variance (ANOVA) was carried out using SPSS Software v.21.<br> <strong>Results: </strong>Results showed that eight weeks of resistance training with pomegranate juice consumption significantly increased GLP-1, HDL, insulin (<em>p</em> = 0.0001) and decreased DPP-4, LDL and glucose (<em>p</em> = 0.0001) levels in women with type 2 diabetes. Furthermore, results showed that resistance training significantly increased GLP-1 and decreased DDP-4 levels in these women. No significant changes were seen in control group and pomegranate juice consumption in the study variables.<br> <strong>Conclusions: </strong>Based on the results of this study, resistance training with consumption of pomegranate juice effectively improves insulin secretion and glycemic control. This improvement can be attributed to increases in GLP-1 and DDP-4 levels. Type 2 diabetes, Pomegranate juice, Resistance exercise, Glucagon-like peptide-1, Inhibitors of dipeptidyl peptidase 4 5 10 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-870-1&slc_lang=en&sid=1 Mohsen Akbarpour akbarpour.mohsen@gmail.com 10031947532846004760 10031947532846004760 No Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, University of Qom, Qom, Iran Fazlollah Fathollahi Shoorabeh f.fathollahi1984@gmail.com 10031947532846004761 10031947532846004761 Yes 2- Nutritional Health Research Center, Lorestan University of Medical Sciences Mahnaz Mardani msmardani@yahoo.com 10031947532846004762 10031947532846004762 No 2- Nutritional Health Research Center, Lorestan University of Medical Sciences Fatemeh Amini Majd aminimajd73@gmail.com 10031947532846004763 10031947532846004763 No 1- Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, University of Qom, Qom, Iran