en Food Science Food Science پژوهشي Research <strong>Background and Objectives: </strong>Bisphenol-A (BPA) is a substance used in epoxy resin monomers and polycarbonate plastics. This research focuses on the effect of Bisphenol A on histology alterations in prefrontal cortex (PFC) of rats.<br> <strong>Materials and Methods: </strong>Thirty male rats were divided into 3 groups: A control group, a placebo group received distilled water intra peritoneal and the experiment group received 1.0&micro;g/kg BPA intra peritoneal for 14 days. After 2 weeks, rat&rsquo;s brains were enucleated, sequenced in 10&micro;m widths and HE stained for histological examinations. Neural and neuroglia cells were counted and rats&rsquo; PFC volume was measured using stereological methods.<br> <strong>Results: </strong>Our results showed statistically significant decreases in PFC volume and neural cell count in the experiment group in comparison to both placebo and control groups. Also, results showed statistically significant increases in glial cell count in the experiment group in comparison to other groups.<br> <strong>Conclusions: </strong>This research showed that BPA has negative and pathological effects on neural cells and PFC in rats Bisphenol A, Prefrontal cortex, Rats 51 56 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-858-1&slc_lang=en&sid=1 Farid Habibi f_habibi1992@yahoo.com 10031947532846005002 10031947532846005002 No Department of Anatomical Sciences &Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Shabnam Movassaghi sm_movassaghi@yahoo.com 10031947532846005003 10031947532846005003 No Department of Anatomical Sciences &Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Amirhossein saeinia saeinea@yahoo.com 10031947532846005004 10031947532846005004 No Department of Anatomical Sciences &Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Mohammad Mahdi Nazarnejad Nazarnejad2001@gmail.com 10031947532846005005 10031947532846005005 No Department of Anatomical Sciences &Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Shabnam Abdi shabnam.abdi62@yahoo.com 10031947532846005006 10031947532846005006 Yes Department of Anatomical Sciences &Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran