en Nutrition Nutrition پژوهشي Research <strong>Background and Objectives: </strong>Strenuous exercises have been shown to induce inflammation. However, consumption of products rich in antioxidants such as vitamin C may enhance this effect. The purpose of this study was to assess effects of vitamin C supplementation on C-reactive protein, lactate and blood pressure following resistance exercise in overweight men.<br> <strong>Materials and Methods: </strong>In a randomized, double-blinded placebo-controlled trial, 20 young men (age of 38.8 y &plusmn;3.4 and BMI of 28.36 kg/m²&plusmn;1.2) voluntarily participated and were randomly divided into vitamin C supplementation<br> (n = 10) and placebo (n = 10) groups. After two weeks of receiving 500 mg/d of vitamin C or placebo, participants were involved in a session of resistance exercises (three sets of eight repetitions at 80% of one repetition maximum). To assess changes in C-reactive protein and lactate, blood samples were collected after blood pressure measurement at phases of baseline, pre exercise, immediately post resistance exercise and 24 h post exercise.<br> <strong>Results: </strong>Results using ANOVA with repeated measurement showed that levels of C-reactive protein, lactate and systolic and diastolic blood pressure were not significantly changed in participants after supplementation (<em>p</em>>0.05). Moreover, significant increases were seen in lactate and systolic and diastolic blood pressure immediately after exercise intervention in both groups (<em>p </em>< 0.05). However, C-reactive protein levels significantly increased only in placebo group immediately post resistance exercise and 24 h post exercise, compared to those at baseline (<em>p </em>= 0.008 and <em>p </em>= 0.021, respectively) and pre exercise (<em>p</em> = 0.007, and <em>p </em>= 0.019, respectively) times. The unique statistically significant difference between the two groups included a significant increase in level of C-reactive protein in placebo group immediately post resistance exercise (<em>p</em> = 0.031) and 24 h post exercise (<em>p</em> = 0.038) times, compared to supplement group.<br> <strong>Conclusions: </strong>Results from the present study have demonstrated the beneficial effects of vitamin C supplement on improved blood pressure and lactate tolerance as well as decreased inflammatory responses of C-reactive protein caused by resistance exercises. Physical activity, Inflammation, Blood pressure, Lactic Acid, CRP 21 28 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-857-1&slc_lang=en&sid=1 Mehdi Hakimi Mehdihakimi66@yahoo.com 10031947532846004764 10031947532846004764 Yes Assistant Professor of Exercise Physiology of Cardiovascular and Respiration, Department of Physical Education & Sport Science, Marivan Branch, Islamic Azad University, Marivan, Iran. Araz Mohammadi Mehdihakimi66@yahoo.com 10031947532846004765 10031947532846004765 No MSc in Exercise Physiology of Physical Activity and Wellness, Department of Physical Education & Sport Science, Marivan Branch, Islamic Azad University, Marivan, Iran