en Nutrition Nutrition پژوهشي Research <strong>Background and Objectives: </strong>Curcumin and exercise training are suggested to improve hepatic disorders. The aim of this study was to investigate effects of two weeks of swimming training and curcumin supplementation on platelet-derived growth factor (PDGF-BB) and transforming growth factor beta 1 (TGF-&beta;1) gene expressions following ethanol consumption in Wistar male rats.<br> <strong>Materials and Methods: </strong>Totally, 32 Wistar male rats were divided into four equal groups, including control, exercise, curcumin and curcumin-exercise groups. Ethanol was gavaged to all groups (g kg^-1) for four days. Then, the renunciation period (four days) started. The exercise period included two weeks, each week included five sessions of exhaustive swimming. Curcumin supplementation (50 mg kg^-1) was used with trainings.<br> <strong>Results: </strong>Curcumin supplementation demonstrated significant decreases in expression of PDGF-BB (<em>P</em> = 0.025) and TGF-&beta;1 (<em>P</em> = 0.033) genes. In exercise groups, significant decreases were seen in expression of PDGF-BB (<em>P </em>= 0.007) and TGF-&beta;1 (<em>P</em> = 0.001) genes. Interaction of exercise and curcumin resulted in significant decreases in expression of PDGF-BB (<em>P</em> = 0.040) and TGF-&beta;1 (<em>P</em> = 0.013) genes.<br> <strong>Conclusions: </strong>In conclusion, expression decreases in PDGF-BB and TGF-&beta;1 genes suggest that exercise and curcumin consumption can protect hepatic tissues through controlling hepatic satellite cell (HSC) activation, preventing negative effects of ethanol. Curcumin, Exercise training, Ethanol, PDGF-BB, TGF-β1 33 40 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-812-1&slc_lang=en&sid=1 Hoseyn Dalvand hdal26@yahoo.com 10031947532846003974 10031947532846003974 No Department of Physiology of Sport,Borujerd Branch, Islamic Azad University, Borujerd, Iran Ahmad Hematfar ahematfar@yahoo.com 10031947532846003975 10031947532846003975 Yes Department of Physiology of Sport,Borujerd Branch, Islamic Azad University, Borujerd, Iran Naser Behpoor n_behpoor@yahoo.com 10031947532846003976 10031947532846003976 No Department of Physiology of Sport,Borujerd Branch, Islamic Azad University, Borujerd, Iran