en Nutrition Nutrition پژوهشي Research <strong>Background and Objectives: </strong>Aerobic training and berberine chloride include antioxidant and anti-inflammatory characteristics. In the current study, simultaneous effects of aerobic training and berberine chloride on plasma glucose, IL-6 and TNF-&alpha; were investigated in type 1 diabetic male Wistar rats.<br> <strong>Materials and Methods: </strong>In this experimental study, 64 male Wistar rats were randomly divided into eight groups<br> (<em>n</em>=8), including healthy control, diabetic control, diabetic-berberine (15 and 30 mg/kg), diabetic-training, diabetic-training-berberine (15 and 30 mg/kg) and health-trained. Diabetes was induced using a single intraperitoneal injection (IP) of streptozotocin (STZ) of 60 mg/kg body weight (BW). The training schedule included running on a treadmill for six weeks, five sessions a week and daily intakes of berberine using gavage. The IL-6 and TNF-&alpha; values were assessed using enzyme-linked immunosorbent assay (ELISA) method.<br> <strong>Results: </strong>Results showed that the glucose concentration in diabetic groups with aerobic training and intake of berberine simultaneously was significantly lower than that in the diabetic control group (<em>P</em><0.05). Plasma IL-6 in the diabetic control group significantly increased, compared to that in the normal control group (<em>P</em><0.05). In diabetic groups that received the two treatments simultaneously, IL-6 significantly increased, compared to that in the diabetic control group (<em>P</em><0.05). The quantity of TNF-&alpha; in the diabetic control group was significantly higher than that in the normal control group (<em>P</em><0.05). The plasma level of TNF-&alpha; significantly decreased in all treatment groups, compared to that in the diabetic control group (<em>P</em><0.05).<br> <strong>Conclusions: </strong>Combined effects of berberine chloride use and aerobic training on blood glucose, IL-6 and TNF- &alpha; are more evident than their individual effects. Furthermore, a dose of 30 mg/kg of berberine chloride included a greater effect on the highlighted blood parameters, compared to that a dose of 15 mg/kg of berberine chloride did.<br> <span dir="RTL"></span> Type 1 Diabetes, Aerobic training, Berberine chloride, IL-6, TNF-α 9 16 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-676-1&slc_lang=en&sid=1 Javad Ramezani ramezani.javad@gmail.com 10031947532846003479 10031947532846003479 No Central Tehran Branch, Islamic Azad University, Tehran, Iran Mohammad Ali Azarbayjani Ali.azarbayjani@gmail.com 10031947532846003480 10031947532846003480 Yes Central Tehran Branch, Islamic Azad University, Tehran, Iran Maghsoud Peeri m.peeri@gmail.com 10031947532846003481 10031947532846003481 No Central Tehran Branch, Islamic Azad University, Tehran, Iran