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Nutr Food Sci Res 2020, 7(1): 9-16 Back to browse issues page
Effects of Aloe Vera and Swimming Training on Lipid Profile of Streptozotocin Induced Diabetic Rats
Ali Hosseini , Fariba Khoshsovt , Mozhgan Ahmadi , Mohammad Ali Azarbayjani , Omidreza Salehi , Fatemeh Farkhaie
Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Abstract:   (1681 Views)
Background and Objectives: Exercise and nutrition are two effective factors in controlling diabetes-induced metabolic disorders. The aim of this study was to assess effects of aloe vera and swimming training on lipid profile of the diabetic rats.
Materials and Methods: In this experimental study, 72 diabetic rats were selected and divided into nine groups of eight rats, including 1) four weeks of aloe vera consumption (FAV), 2) six weeks of aloe vera consumption (SAV), 3) four weeks of swimming (FS), 4) six weeks of swimming (SS), 5) four weeks of aloe vera consumption with swimming (FAVS), 6) six weeks of aloe vera consumption with swimming (SAVS), 7) Week-1 diabetic control (DC), 8) Week-4 diabetic control (FDC), and 9) Week-6 diabetic control (SDC). Groups 1, 2, 5 and 6 received 100 mg kg-1 of aloe vera daily. Furthermore, Groups 3 and 5 swam for four weeks and Groups 4 and 6 for six weeks, five sessions per week and 30 minutes each session. Data were analyzed using one-way ANOVA, two-way ANOVA and Bonferroni post-hoc tests (P≤0.05).
Results: Results showed that training, aloe vera and aloe vera with training significantly decreased levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) (P≤0.05); four and six weeks of swimming trainings decreased TG, TC, LDL and VLDL (P≤0.05); and six weeks of aloe vera consumption decreased TG, TC, LDL and VLDL (P≤0.05).
Conclusions: Four and six weeks of aloe vera consumption and swimming training include interactive lipid lowering effects in streptozotocin induced diabetic rats.

Keywords: Training, Aloe vera, Diabetes, Lipid profile
Full-Text [PDF 564 kb]   (594 Downloads)    
Article type: Research | Subject: nutrition
Received: 2019/03/16 | Accepted: 2019/07/18 | Published: 2020/01/28
1. Howarth F, Marzouqi F, Salem Al Saeedi A, Shaul Hameed R, Adeghate E. The effect of a heavy exercise program on the distribution of pancreatic hormones in the streptozotocininduced diabetic rat. JOP 2009; 10 (5): 485- 491.
2. Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004; 24 (5): 816- 823. [DOI:10.1161/01.ATV.0000122852.22604.78]
3. Soedamah-Muthu SS1, Fuller JH, Mulnier HE, Raleigh VS, Lawrenson RA, Colhoun HM. High risk of cardiovascular disease in patients with type 1 diabetes in the U.K.: a cohort study using the general practice research database. Diabetes Care 2006; 29 (4): 798- 804. [DOI:10.2337/diacare.29.04.06.dc05-1433]
4. Grauslund J, Jorgensen TM, Nybo M, Green A, Rasmussen LM, Sjolie AK. Risk factors for mortality and ischemic heart disease in patients with long-term type 1 diabetes. J Diabetes Complications 2010; 24: 223- 228. [DOI:10.1016/j.jdiacomp.2009.05.003]
5. Sreelatha S, Inbavalli R. Antioxidant, antihyperglycemic, and antihyperlipidemic effects of coriandrumsativum leaf and stem in alloxan-induced diabetic rats. J Food Sci. 2012; 77(7): 119- 123. [DOI:10.1111/j.1750-3841.2012.02755.x]
6. Can A, Akev N, Ozsoy N, Bolkent S, Arda BP, Yanardag R, et al. Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Biol Pharm Bull 2004; 27 (5): 694- 698. [DOI:10.1248/bpb.27.694]
7. Parihar M, Chaudhary M, Shetty R, Hemnani T. Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: prevention by extracts of Withania somnifera and Aloe vera. J Clin Neur 2004; 11(4): 397- 402. [DOI:10.1016/j.jocn.2003.09.008]
8. Rajasekaran S, Aathishsekar D. Therapeutic evaluation of Aloe vera leaf gel extract on glycoprotein components in rats with streptozotocin diabetes. J Pharm Tox 2007; 2(4): 380- 385. [DOI:10.3923/jpt.2007.380.385]
9. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes care 2003; 26 (4): 1277- 1294. [DOI:10.2337/diacare.26.4.1277]
10. Rajasekaran S, Sivagnanam K, Subramanian S. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol Rep 2005; 57 (1): 90- 96. [DOI:10.1385/BTER:108:1-3:185]
11. Duncan GE, Anton SD. Prescribing exercise at varied levels of intensity and frequency: A randomized trial. Arch Intern Med 2005; 165: 2362- 2366. [DOI:10.1001/archinte.165.20.2362]
12. Tabatabaei SRF, Ghaderi S, Bahrami-Tapehebur M, Farbood Y, Rashno M. Aloe vera gel improves behavioral deficits and oxidative status in streptozotocin-induced diabetic rats. Biomed Pharmacother. 2017; 96:279-290. [DOI:10.1016/j.biopha.2017.09.146]
13. Ayoubi A, Omidi A, Valizade R, Mousaei A. Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats. J Birjand Univ Med Sci 2013; 20 (2): 144- 152.
14. Askari M, Hoseini A. Effect of hydroalcoholic extracts of Anethum graveolens L. with swimming training on lipid profile of diabetic rats. Horizon Med Sci 2016; 22 (4): 345- 351. [DOI:10.18869/acadpub.hms.22.4.345]
15. Zar A, Hoseini‎ A, Ahmadi F, Rezaei M. Effects of ginger together with swimming training on blood fat profiles in adult diabetic rats with streptozotocin. Iranian J Nutr Scie Food Tech 2016; 11 (2): 65- 74.
16. Joshi SC, Gajraj A. Induction of hypocholesterolemia associated with testicular dysfunction by Aloe Barbedensis in Albino Rats. Pharm J 2006; 3: 1- 8.
17. Kim K, Kim H, Kwon J, Lee S, Kong H, Im S-A, et al. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. Phyto Med 2009; 16 (9): 856- 863. [DOI:10.1016/j.phymed.2009.02.014]
18. Kamal-Eldin A, Moazzami A. Plant sterols and stanols as cholesterol-lowering ingredients in functional foods. Rec Pat Food Nutr Agrical 2009; 1 (1): 1- 14. [DOI:10.2174/2212798410901010001]
19. Beppu, Shimpo K, Chihara T, Kaneko T, Tamai I, Yamaji S, Ozaki S, Kuzuya H, Sonoda S. Antidiabetic effects of dietary administration of Aloe Arborescens Miller components on multiple low-dose streptozotocin-Induced diabetes in mice: Investigation on hypoglycemic action and systemic absorption dynamics of Aloe Components. J Ethnopharm 2006; 103 (3): 468- 477. [DOI:10.1016/j.jep.2005.10.034]
20. Misawa E, Tanaka M, Nomaguchi K, Nabeshima K, Yamada M, Toida T, et al. Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats. J Agricul Food Chem 2012; 60 (11): 2799- 2806. [DOI:10.1021/jf204465j]
21. Tanaka M, Misawa E, Ito Y, Habara N, Nomaguchi K, Yamada M, et al. Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol Pharma Bull 2006; 29 (7): 1418- 1422. [DOI:10.1248/bpb.29.1418]
22. Manjunath CN, Rawal JR, Mehelli Irani P, Madhu K. Atherogenic dyslipidemia. Indian J Endocrinol Metab. 2013; 17(6): 969-976. [DOI:10.4103/2230-8210.122600]
23. Castro AV, Kolka CM, Kim SP, Bergman RN. Obesity, insulin resistance and comorbidities? Mechanisms of association. Arq Bras Endocrinol Metabol. 2014;58(6):600-9. [DOI:10.1590/0004-2730000003223]
24. Park JH, Lee YE. Effects of exercise on glycemic control in type 2 diabetes mellitus in Koreans: the fifth Korea National Health and Nutrition Examination Survey (KNHANES V). J Phys Ther Sci. 2015; 27(11): 3559-3564. [DOI:10.1589/jpts.27.3559]
25. Pedralli ML, Waclawovsky G, Camacho A, Markoski MM, Castro I, Lehnen AM. Study of endothelial function response to exercise training in hypertensive individuals (SEFRET): study protocol for a randomized controlled trial. Trials. 2016 Feb 13; 17:84. [DOI:10.1186/s13063-016-1210-y]
26. Kang S, Woo JH, Shin KO, Kim D, Lee H-J, Kim YJ, et al. Circuit resistance exercise improves glycemic control and adipokines in females with type 2 diabetes mellitus. J Sports Sci Med 2009; 8: 682- 688.
27. Terada T, Friesen A, Chahal B S, Bell GJ, McCargar LJ, Boulé NG. Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes. Diabetes Res Clin Pract 2013; 99: 120- 129. [DOI:10.1016/j.diabres.2012.10.019]
28. Aggarwala J, Sharma S, Jain A, Sarkar A. Effects of aerobic exercise on blood glucose levels and lipid profile in Diabetes Mellitus type 2 subjects. Al Ameen J Med Sci 2016; 9(1): 65- 69.
29. Khademosharie M, Amiri Parsa T, Hamedinia M R, Azarnive M A, Hosseini-Kakhk S A R. Effects of two aerobic training protocols on Vaspin, Chemerin and lipid profile in women with type 2 diabetes. Iran South Med J 2014; 17 (4): 571- 581.
30. Mokhtari F, Esfarjani F, Kargar Fard M. The effect of combined aerobic exercise and barley b-glucan on lipid profile and glucose blood of women with diabetes type two. IJDLD 2014; 13 (4): 340- 351.
31. Yavari A, Najafipoor F, Aliasgarzadeh A, Niafar M, Mobasseri M. Effect of aerobic exercise, resistance training or combined training on glycaemic control and cardiovascular risk factors in patients with type 2 diabetes. Biol Sport 2012; 29: 135- 143. [DOI:10.5604/20831862.990466]

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