:: دوره 5، شماره 3 - ( 3-1397 ) ::
جلد 5 شماره 3 صفحات 3-10 برگشت به فهرست نسخه ها
ارزیابی اثربخشی مکمل یاری ویتامین D با دوزهای IU/d 1000 و IU/d 2000 در دوران بارداری بر وضعیت ویتامین D ، بیومارکرهای متابولیک، التهابی و استرس اکسیداتیو مادر و خون بند ناف، و پیامدهای بارداری و نوزادی: پروتکل مطالعه
چکیده:   (3275 مشاهده)
Background and Objectives: Vitamin D deficiency during pregnancy is prevalent throughout the world and has been associated with complications in mothers and infants. The aim of this study is to evaluate the efficacy of two doses of vitamin D supplementation (1000 IU/d versus 2000 IU/d) during pregnancy on maternal and cord blood vitamin D status, metabolic, inflammatory and oxidative stress biomarkers as well as maternal and neonatal outcomes (birth size and Apgar score).
Methods: A total of 84 pregnant women with the eligible criteria are randomly allocated to one of the two supplementation groups: (a) 1000 IU/d vitamin D which is routinely given to pregnant women, and (b) 2000 IU/d. Biochemical assessments of mothers are performed at the beginning and 34 weeks of gestation. They include serum concentrations of 25-hydroxycalciferol (25(OH)D), calcium, phosphate, intact parathyroid hormone (iPTH), fasting serum glucose (FSG), insulin, lipid profile including triglycerides (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL_C), as well as high sensitivity C-reactive protein (hs-CRP) and the maternal cell-culture supernatant concentrations of inflammatory cytokines IL-1β, IL-6 and TNF-α. Assessments of infants at delivery comprise cord blood serum concentrations of 25(OH)D, iPTH, hs-CRP, IL-1β, IL-6, TNF-α birth sizes and Apgar score.
Discussion: The results obtained from the clinical efficacy trials on the appropriate dose for vitamin D supplementation during pregnancy are controversial. The current study could be a step to attenuate the existent controversy on evaluating the efficacy of two doses of vitamin D supplement on a wide spectrum of both mother and newborn outcomes. Meanwhile our study could give a clue to the policy-makers at MOH by revealing the efficacy of currently prescribed 1000 IU/d vitaminD3 versus 2000 IU/d.
متن کامل [PDF 139 kb]   (1070 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: تغذیه
دریافت: 1397/5/15 | پذیرش: 1397/6/26 | انتشار: 1397/6/26



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دوره 5، شماره 3 - ( 3-1397 ) برگشت به فهرست نسخه ها