:: Volume 5, Issue 2 (Apr-Jun 2018) ::
Nutr Food Sci Res 2018, 5(2): 11-17 Back to browse issues page
The Association between Amino Acid Intake and Polycystic Ovary Syndrome in Women Who Referred to Isfahan University of Medical Science Clinics
Golnaz Rajaeieh , Nafiseh Shokri Mashhadi , Morteza Safavi , Zahra Amini Pozveh , Ali Pezeshki
Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Behehshti University of Medical Sciences, Tehran, Iran , asmaneshab@gmail.com
Abstract:   (4920 Views)

Background and Objectives: Polycystic ovary syndrome (PCOS) is the greatest current endocrine disease in generative women. Although other issues such as insulin resistance, hyperinsulinemia, adiposity and dietary pattern are implied to be connected to PCOS, but the most recent evidence are needed to improve management of PCOS. Proteins and amino acids (key dietary components) can also have impact on this condition and may have therapeutic effects for handling this disorder. However, there is little information available in this area. So, the purpose of this study was to assess the connection between amino acids and protein intake and PCOS.
Materials and Methods: Science, Iran. Amino acids and proteins intake was estimated using validated food frequency questionnaire. Other factors such as ovarian disease, inherited predisposition, physical activity, the age of menarche and medical history were assessed by the questionnaire. Data analysis was represented by adjusted logistic by SPSS software version 15.
Results: The marked association among PCOS and ovarian disease (P < 0.001), age (P < 0.001) and consuming drugs (P = 0.001) were seen.  There was inversely associated between body mass index (BMI) and PCOS, but it was not remarkable (P = 0.068). But, no statistically significant connection was seen between the use of LEU (Lucien), MET (methionine), CYS (cysteine), PHE (phenylalanine), VAL (valine), ASP (asparagines), GLU (glutamic acid), and PCOS. Although, there was significant relationship between glycine, prolin, and methionine with PCOS.
Conclusions: According to the results of this study, significant relationship was observed between glycine, prolin, and methionine and BCAA/AAA ratio with PCOS.
 
Keywords: Protein products, Amino acids, Polycystic ovary syndrome
Full-Text [PDF 115 kb]   (4806 Downloads)    
Article type: Research | Subject: Nutrition
Received: 2017/06/24 | Accepted: 2018/01/14 | Published: 2018/03/11
References
1. Rajaeieh G, Marasi M, Zahra Shahshahan, Fatemmeh Hassanbeigi F, Safavi SM. The Relationship between Intake of Dairy Products and Polycystic Ovary Syndrome in Women Who Referred to Isfahan University of Medical Science Clinics in 2013. Int J Prev Med 2014; 6: 687–694.
2. Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010 May 1;93(7):2222-31. [DOI:10.1016/j.fertnstert.2009.01.100]
3. Gambineri A, Patton L, Vaccina A, Cacciari M, Morselli-Labate AM, Cavazza C, et al. Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study. J. Clin. Endocrinol. Metab 2006; 10: 3970-3980. [DOI:10.1210/jc.2005-2250]
4. Le Donne M, Alibrandi A, Giarrusso R, Lo Monaco I, Muraca U, Ginecologica M. Diet, metformin and inositol in overweight and obese women with polycystic ovary syndrome: Effects on body composition. Minerva Ginecol 2012; 1: 23-29.
5. Pasquali R, Gambineri A, Cavazza C, Ibarra Gasparini D, Ciampaglia W, Cognigni GE, et al. Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndrome. Eur J Endocrinol 2011; 1:53-60. [DOI:10.1530/EJE-10-0692]
6. Artimani T, Saidijam M, Aflatoonian R, Amiri I, Ashrafi M, Shabab N, et al. Estrogen and progesterone receptor subtype expression in granulosa cells from women with polycystic ovary syndrome. Gynecol Endocrinol 2015; 5: 379-383. [DOI:10.3109/09513590.2014.1001733]
7. Norman RJ, Dewailly D, Legro RS, Hickey T E. Polycystic ovary syndrome. The Lancet 2007; 370: 685-697. [DOI:10.1016/S0140-6736(07)61345-2]
8. Pirak A, Kashani ZA, Azarkish F, Salehian T, Hagani H, Parsania Z, et al. A study on correlation between gestational diabetes and history polycystic ovary syndrome in women referred to Akbar Abady Hospital in Tehran 1998-2005.Sci J Ilam Univ Med Sci 2009; 4:17-25
9. Motta AB. The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des 2012; 10:2482-2491. [DOI:10.2174/13816128112092482]
10. Kachoie A, Jahanipoor A, Ghahiri A. Evaluation of serum prolactin levels in patients with polycystic ovary syndrome. J Isfahan Med Sch 2012; 182: 353-358.
11. Barba G, Russo P. Dairy foods, dietary calcium and obesity: A short review of the evidence. Nutr Metab Cardiovasc Dis 2006; 6: 445-451. [DOI:10.1016/j.numecd.2006.04.004]
12. Hajishafieha M. Causes and treatment of chronic anovulation: Institute Publications, Witnessed and Veterans; 2003.
13. Salmabadi Z, Mohseni-Kouchesfahani H, Parivar K, Karimzadeh L. Effect of grape seed extract on lipid profile and expression of interleukin-6 in polycystic ovarian syndrome wistar rat model. Int J Fertil Steril 2017; 3: 176-183.
14. Salih SM., Salama SA, Fadl AA, Nagamani M, Al-Hendy A. Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma. Int J Fertil Steril 2008; 3: 789-797. [DOI:10.1016/j.fertnstert.2007.01.042]
15. Szczuko M, Zapałowska-Chwyć M, Maciejewska D, Drozd A, Starczewski A, Stachowska E. High glycemic index diet in PCOS patients. The analysis of IGF I and TNF-α pathways in metabolic disorders. Med. hypotheses 2016: 42-47. [DOI:10.1016/j.mehy.2016.09.016]
16. Ahmadi A, Akbarzadeh M, Mohammadi F, Akbari M, Jafari B, Tolide-Ie H. Anthropometric characteristics and dietary pattern of women with polycystic ovary syndrome. Indian J Endocrinol Metab 2013; 4: 672–676.
17. Oono T, Yamasaki T, Zaitsu J, Saeki I, Iwamoto T, Harima Y, et al. Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease. Hepatol Res 2014; 10: E54-E62 [DOI:10.1111/hepr.12213]
18. Noakes M, Keogh JB, Foster PR, Clifton PM. Effect of an energy- restricted, high- protein, low-fat diet relative to a conventional high- carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women. Am J Clin Nutr 2005; 6:1298-1306. [DOI:10.1093/ajcn/81.6.1298]
19. Hosseini-Esfahani F, Asghari G, Mirmiran P, Farahani PJ, Azizi F. Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the theran lipid and glucose study. Razi J Med Sci 2010; 6: 41-55.
20. Zhang C, Zhao Y, Li R, Yu Y, Yan L, Li L, et al. Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome. Zhang et al. BMC Pregnancy Childbirth 2014; 11: 1-7
21. Sørensen LB1, Søe M, Halkier KH, Stigsby B, Astrup A. Effects of increased dietary protein-to-carbohydrate ratios in women with polycystic ovary syndrome. Am J Clin Nutr 2012; 1: 39-48 [DOI:10.3945/ajcn.111.020693]
22. Azadbakht L, Esmaillzadeh A. Red meat intake is associated with metabolic syndrome and the plasma C-reactive protein concentration in women. J Nutr 2008; 2: 335-339.
23. Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N. Low grade chronic inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metab 2001; 6: 2453-2455. [DOI:10.1210/jcem.86.6.7580]
24. Amato G, Conte M, Mazziotti G, Lalli E, Vitolo G, Tucker AT, et al. Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles. Obstet Gynecol 2003; 6: 1177-1182.
25. Garcia-Macedo R, Sanchez-Munoz F, Almanza-Perez JC, Duran-Reyes G, Alarcon-Aguilar F, Cruz M. Glycine increases mRNA adiponectin and diminishes pro-inflammatory adipokines expression in 3 T3-L1 cells. Eur J Pharmacol 2008; 3: 317-321. [DOI:10.1016/j.ejphar.2008.03.051]
26. Spittler A, Reissner CM, Oehler R, Gornikiewicz A, Gruenberger T, Manhart N, et al. Immunomodulatory effects of unit on LPS-treated monocytes: reduced TNF-alpha production and accelerated IL-10 expression. FASEB J 1999; 3: 563-571. [DOI:10.1096/fasebj.13.3.563]
27. Alarcon-Aguilar FJ, Almanza-Perez J, Blancas G, Angeles S, Garcia-Macedo R, Roman R, et al. Glycine regulates the production of pro-inflammatory cytokines in lean and monosodium glutamate-obese mice. Eur J Pharmacol 2008; 3: 152-158 [DOI:10.1016/j.ejphar.2008.09.047]
28. Montgomery-Rice V, Limback SD, Roby KF, Terranova PF. Differential responses of granulosa cells from small and large follicles to follicle stimulating hormone (FSH) during the menstrual cycle and acyclicity: effects of tumour necrosis factor-alpha. Hum Reprod 1998; 5: 1285-1291. [DOI:10.1093/humrep/13.5.1285]
29. Vural P, Degirmencioglu S, Saral NY, Akgul C. Tumor necrosis factor alpha (-308), interleukin-6 (-174) and interleukin-10 (-1082) gene polymorphisms in polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2010; 1: 61-65. [DOI:10.1016/j.ejogrb.2010.02.010]
30. Cruz M, Maldonado-Bernal C, Mondragon-Gonzalez R, Sanchez-Barrera R, Wacher NH, Carvajal-Sandoval G, et al. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes. J Endocrinol Invest 2008; 8: 694-699. [DOI:10.1007/BF03346417]
31. Sekhar RV, McKay SV, Patel SG, Guthikonda AP, Reddy VT, Balasubramanyam A, et al. Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care 2011; 1: 162-167. [DOI:10.2337/dc10-1006]
32. Kikuchi G, Hiraga K. The mitochondrial glycine cleavage system. Unique features of the glycine decarboxylation. Mol Cell Biochem 1982; 3: 137-149
33. Zhao Y, Li F, Li R, Wang L, Yan Yang, Liu N,et al. Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis. BMC Med 2012; 10:153 [DOI:10.1186/1741-7015-10-153]
34. Carmina E, Guastella E, Longo RA, Rini GB, Lobo RA. Correlates of increased lean muscle mass in women with polycystic ovary syndrome. Eur J of endocrinol 2009; 583-589. [DOI:10.1530/EJE-09-0398]
35. Murray, Robert K, Peter L. Gross. "Harper's Illustrated Biochemistry, 2012.
36. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, et al. MAP kinases. Chem rev 2009; 8: 2449-2476.

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