en Nutrition Nutrition Review Review <span style="font-size:10pt"><span style="line-height:115%"><span style="tab-stops:409.5pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><i>Ziziphus jujuba</i>, commonly known as jujube, is a medicinal fruit with a long ethnopharmacological history in Persian and Eastern traditional medicine. Increasing evidence has highlighted its diverse bioactive profile and potential physiological relevance in modulating fatigue, psychological stress, inflammation and metabolic recovery. This narrative review synthesized multidisciplinary findings on the phytochemical composition, pharmacological mechanisms and physiological implications of <i>Ziziphus jujuba</i> associated to stress and recovery processes. A comprehensive literature search was carried out within PubMed, Scopus and Web of Science (up to May 2025), including <i>in vitro</i>, animal and human studies investigating its effects on biochemical, neurophysiological and metabolic parameters. The primary bioactive constituents saponins, flavonoids and jujubosides exert neuroprotective, antioxidant and anti-inflammatory effects through modulation of central nervous system signaling, cytokine expression, oxidative balance and sleep regulation. Such mechanisms support physiological resilience and recovery from exercise-induced or stress-associated fatigue. Additionally, cardiometabolic benefits, including improved insulin sensitivity, lipid modulation and blood pressure regulation, have been reported. Practical considerations for the integration of jujube into nutritional and pharmacological support strategies were discussed, with emphasis on dose, timing and potential interactions. Although preclinical and limited clinical evidence supports its adaptogenic and restorative actions, rigorous randomized controlled trials are warranted to clarify causal mechanisms and translational potential. Overall, <i>Ziziphus jujuba</i> represents a promising phytotherapeutic candidate for modulating neuroimmune, oxidative and metabolic pathways linked to human recovery physiology.<b> </b></span></span></span></span></span> Ziziphus jujuba, Phytochemistry, Pharmacology, Oxidative stress, Inflammation, Recovery physiology, Adaptogenic activity 31 45 http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-1180-1&slc_lang=en&sid=1 Babak Hooshmand-Moghadam b.hooshmand@um.ac.ir 10031947532846007225 10031947532846007225 Yes Assistant Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran Abbas Ali Gaeini aagaeini@ut.ac.ir 10031947532846007226 10031947532846007226 No Professor, Department of Exercise Physiology, Faculty of Sports and Health Sciences, University of Tehran, Tehran, Iran Amir Rashidlamir rashidlamir@um.ac.ir 10031947532846007227 10031947532846007227 No Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran