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Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β1 Gene Expressions in Alcoholic Rats
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چکیده: (2753 مشاهده) |
Background and Objectives: Curcumin and exercise training are suggested to improve hepatic disorders. The aim of this study was to investigate effects of two weeks of swimming training and curcumin supplementation on platelet-derived growth factor (PDGF-BB) and transforming growth factor beta 1 (TGF-β1) gene expressions following ethanol consumption in Wistar male rats.
Materials and Methods: Totally, 32 Wistar male rats were divided into four equal groups, including control, exercise, curcumin and curcumin-exercise groups. Ethanol was gavaged to all groups (g kg-1) for four days. Then, the renunciation period (four days) started. The exercise period included two weeks, each week included five sessions of exhaustive swimming. Curcumin supplementation (50 mg kg-1) was used with trainings.
Results: Curcumin supplementation demonstrated significant decreases in expression of PDGF-BB (P = 0.025) and TGF-β1 (P = 0.033) genes. In exercise groups, significant decreases were seen in expression of PDGF-BB (P = 0.007) and TGF-β1 (P = 0.001) genes. Interaction of exercise and curcumin resulted in significant decreases in expression of PDGF-BB (P = 0.040) and TGF-β1 (P = 0.013) genes.
Conclusions: In conclusion, expression decreases in PDGF-BB and TGF-β1 genes suggest that exercise and curcumin consumption can protect hepatic tissues through controlling hepatic satellite cell (HSC) activation, preventing negative effects of ethanol. |
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متن کامل [PDF 531 kb]
(1172 دریافت)
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نوع مطالعه: پژوهشي |
موضوع مقاله:
Nutrition
دریافت: 1398/7/19 | پذیرش: 1398/10/4 | انتشار: 1398/11/8
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