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Vitamin D Deficiency is Associated with the Metabolic Syndrome in Subjects with Type 2 Diabetes
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چکیده: (9556 مشاهده) |
| Background and Objectives: There is convincing evidence that subjects concomitantly affected by type 2 diabetes (T2D) and metabolic syndrome (MeS) are at greater risk for cardiovascular disease (CVD). Many metabolic derangements in T2D might be attributed to poor vitamin D status. The purpose of this study was to investigate the associations among vitamin D status, MeS and glycemic status in subjects with T2D.
Materials and Methods: A total of 101 known cases of T2D (39 males, 62 females) were enrolled in a cross-sectional study by convenient sampling. Serum 25(OH)D3, glycemic markers and lipid profile were assessed.
Results: Mean concentration of serum 25(OH)D3 was 42.2±33.8 nmol/L. Prevalence of undesirable vitamin D status (25(OH)D < 50nmol/L) was significantly higher among the subjects with MeS as compared to those without MeS (p=0.020). The subjects with sufficient vitamin D status had 50% lower risk for MeS compared to those who had vitamin D deficiency, and this association remained significant even after additional adjustment for body mass index (BMI), percent of fat mass or waist circumference.
Conclusions: Our data showed that firstly higher vitamin D status is inversely associated with fasting glycemia, and secondly serum 25(OH)D3 predicts MeS risk in the subjects with T2D. Demonstrating the association of hypovitaminosis D with disorders of glucose metabolism and higher risk for development of further complications, notably CVD, may lead to a new target for preventive efforts at the population level.
Keywords: Vitamin D, Type 2 diabetes, Metabolic syndrome, Cardiovascular disease |
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متن کامل [PDF 139 kb]
(4841 دریافت)
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نوع مطالعه: پژوهشي |
موضوع مقاله:
Nutrition
دریافت: 1392/11/8 | پذیرش: 1393/6/2 | انتشار: 1393/6/2
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