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:: Volume 8, Issue 1 (Jan-Mar 2021) ::
Nutr Food Sci Res 2021, 8(1): 5-10 Back to browse issues page
Effects of Eight Weeks of Resistance Training and Consumption of Pomegranate on GLP-1, DPP-4 and Glycemic Statuses in Women with Type 2 Diabetes: A Randomized Controlled Trial
Mohsen Akbarpour , Fazlollah Fathollahi Shoorabeh , Mahnaz Mardani , Fatemeh Amini Majd
2- Nutritional Health Research Center, Lorestan University of Medical Sciences , f.fathollahi1984@gmail.com
Abstract:   (2454 Views)
Background and Objectives: Diabetes is one of the metabolic diseases with a significant increase rate in recent decades. The aim of this study was to investigate effects of eight weeks of resistance training and consumption of pomegranate juice on Glucagon-like peptide-1(GLP-1), dipeptidyl peptidase 4(DPP-4) and glycemic statuses in women with type 2 diabetes (a randomized controlled trial).
Materials and Methods: Samples included 40 women with type 2 diabetic aged 45–55 years, who were randomly selected and divided into four major groups of control (n = 10), resistance training (n = 10), pomegranate juice consumption (n = 10) and resistance training and pomegranate juice consumption (n = 10) groups. Resistance training group and resistance training and pomegranate juice consumption group carried out three resistance training sessions for eight weeks, each week with a maximum intensity of 30%. By the end of the Week 18, groups reached 80% of the maximum repetition. The pomegranate juice group received 100 ml of pomegranate juice every day. Analysis of variance (ANOVA) was carried out using SPSS Software v.21.
Results: Results showed that eight weeks of resistance training with pomegranate juice consumption significantly increased GLP-1, HDL, insulin (p = 0.0001) and decreased DPP-4, LDL and glucose (p = 0.0001) levels in women with type 2 diabetes. Furthermore, results showed that resistance training significantly increased GLP-1 and decreased DDP-4 levels in these women. No significant changes were seen in control group and pomegranate juice consumption in the study variables.
Conclusions: Based on the results of this study, resistance training with consumption of pomegranate juice effectively improves insulin secretion and glycemic control. This improvement can be attributed to increases in GLP-1 and DDP-4 levels.
Keywords: Type 2 diabetes, Pomegranate juice, Resistance exercise, Glucagon-like peptide-1, Inhibitors of dipeptidyl peptidase 4
Full-Text [PDF 514 kb]   (885 Downloads)    
Article type: Research | Subject: Nutrition
Received: 2020/06/13 | Accepted: 2020/10/7 | Published: 2021/01/3
References
1. Alejandrina C,Carrillo V, Martínez Moreno M, Miramontes H. Potential Hypoglycemic Effect of Pomegranate Juice and Its Mechanism of Action: A Systematic ReviewJournal of Medicinal Food.Jan 2020.23(1):1-11. [DOI:10.1089/jmf.2019.0069]
2. - Akbarpour M, Fathollahi Shoorabeh F, Faraji F. Effect of eight weeks of resistance training with supplementation of pomegranate juice on oxidative. antioxidant factors and lipid profiles in women with type 2 diabetes. Journal of Knowledge & Health 2019;14(3):52-58.
3. Pesta D, Renata L, Anila K, Barbara S, Lauren M. Resistance training to improve type 2 diabetes: working toward a prescription for the future. Nutr Metab (Lond) 2017;14:24 [DOI:10.1186/s12986-017-0173-7]
4. abolfathi F, shabani M, alizadeh A. The Effect of Acute Aerobic Exercise on Glucagon -like peptide-1 (GLP-1) Serum Changes Levels, in Women with Type 2 Diabetes Mellitus. Iranian Journal of Endocrinology and Metabolism. 2017; 18 (6) :432-436
5. Tabibirad S, Abednatanzi H, Nikbakht H, Ghazalian F, Gholami M. EFFECTS OF AEROBIC TRAINING ON DIPEPTIDYL PEPTIDASE-4 AND GLUCAGON-LIKE PEPTIDE-1 IN OBESE WOMEN WITH TYPE 2 DIABETES. ijdld. 2019; 18 (5) :275-281
6. Lee SS, Yoo JH, So YS. Effect of the low- versushigh-intensity exercise training on endoplasmic reticulum stress and GLP-1 in adolescents with type diabetes mellitus. J Phys Ther Sci 2015; 27: 3063-3068. [DOI:10.1589/jpts.27.3063]
7. Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity themetabolic syndrome. Diabetes 2011; 60:1917-25. [DOI:10.2337/db10-1707]
8. Salvo F, Moore N, Arnaud M, et al. Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia: systematic review and meta-analysis. BMJ 2016; 353:i2231. [DOI:10.1136/bmj.i2231]
9. Arnold SV, Yap J, Lam CSP, Tang F, Tay WT, Teng THK, McGuire DK, JanuzziJL, Fonarow GC, Masoudi FA, et al. Management of patients with diabetes and heart failure with reduced ejection fraction: an international comparison. Diabetes Obes Metab. 2019;21(2):261-6. [DOI:10.1111/dom.13511]
10. Chen C, H Ying, Z Yongmei, L Xiyan , Dong G. Targeting the DPP-4-GLP-1 pathway improves exercise tolerance in heart failure patients: a systematic review and meta-analysis. BMC Cardiovascular Disorders.2019:19(12):57-77. [DOI:10.1186/s12872-019-01275-5]
11. Takada S, Masaki Y, Kinugawa S, Matsumoto J, Furihata T, Mizushima W, Kadoguchi T, Fukushima A, Homma T, Takahashi M, et al. Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling. Cardiovasc Res. 2016;111(4):338-47. [DOI:10.1093/cvr/cvw182]
12. Lepore JJ, Olson E, Demopoulos L, Haws T, Fang Z, Barbour AM, Fossler M, Davila-Roman VG, Russell SD, Gropler RJ. Effects of the novel long-acting GLP-1 agonist, Albiglutide, on cardiac function, cardiac metabolism, and exercise capacity in patients with chronic heart failure and reduced ejection fraction. JACC Heart Fail. 2016;4(7):559-66. [DOI:10.1016/j.jchf.2016.01.008]
13. Nejati R, Attarzadeh Hosseini S R, Bijeh N, Raouf Saeb A. The effects of twelve weeks of combined exercises on GLP-1 and insulin resistance in women with type 2 diabetes. JSSU. 2019; 27 (1) :1187-1201. [DOI:10.18502/ssu.v27i1.877]
14. Jafari A, Talebi E, Saqib Joo, M, Fathi R. The effect of aerobic intermittent exercise on plasma levels of acyl ghrelin, tyrosine tyrosine peptide and pseudoglucagon-1 peptide in healthy young men. Sports Physiology, 1398; 11 (41): 105-122.
15. Fathi R, Baqersalimi M, Nazemi M, Khosravi A. Effect of eight weeks of intermittent and continuous walking on serum levels of dipeptidyl peptidase-4 and insulin resistance index in obese 11-9 year old girls. Metabolism and sports activities, 1397; 8 (1): 29-42
16. Yothsna K. The Study of Effect of Pomegranate Juice on Type 2 Diabetes Mellietus. IOSR Journal of Dental and Medical Sciences,2017:16(4):28-30. [DOI:10.9790/0853-1604032830]
17. Zarban A, Malekaneh M, Reza Boghrati M. Antioxidant properties of pomegranate juice and its scavenging effect on free radicals. J Birjand Univ Med Sci. 2007; 14 (3) :9-15.
18. Nojavan F, Danesh A S. The Review of attributes of pomegranate in view of Iranian traditional medicine and Modern medicine. jiitm. 2017; 8 (1) :35-45.
19. Abdi A, Mehrabani J, Haeri T, Shykholeslami Z, Mostafavian M. Protective Effect of Aerobic Training along with Punica granatum L on Cardiac Injury Biomarkers in Women with Type 2 Diabetes. Iranian Journal of Nutrition Sciences & Food Technology. 2019; 13 (4) :1-10.
20. Babaeian amini S, Ebrahimi Mameghani M, Niafar M. The effect of pomegranate juice (no added sugar) consumption on fast blood sugar, lipid profile, antioxidant factors in Type 2 diabetes. yafte. 2016; 18 (3) :95-103.
21. Ueda SY, Yoshikawa T, Katsura Y, Usui T, NakaoH, Fujimoto S. Changes in gut hormone levels andnegative energy balance during aerobic exercise inobese young males. J Endocrinol 2009; 201: 151-9. [DOI:10.1677/JOE-08-0500]
22. Farzanegi P. The effect of aerobic training andArbutin on GLP1 and GLP1R in diabeties Rats.Indian Journal of Fundamental and Applied Life Sciences 2014; 4(4):356-362
23. Heden TD, Liu Y, Kearney ML, Park Y, Dellsperger KC, Thomas TR. Prior exercise and postprandial incretin responses in lean and obese individuals.Med Sci Sports Exerc 2013; 45: 1897. [DOI:10.1249/MSS.0b013e318294b225]
24. Dekker MJ, Graham TE, Ooi TC, Robinson LE.Exercise prior to fat ingestion lowers fasting andpostprandial VLDL and decreases adipose tissue IL-and GIP receptor mRNA in hypertriacylglycerolemic men. J Nutr Biochem: 2010; 983-90. [DOI:10.1016/j.jnutbio.2009.08.004]
25. Chanoine JP, Mackelvie KJ, Barr SI, Wong AC, Meneilly GS and Elahi DH. GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise. Obesity: 2008 :16: 202-204. [DOI:10.1038/oby.2007.39]
26. Sohrab G, Sotoodeh G, Siasi F, Neiestani T, Rahimi A, Chamari M. Effect of Pomegranate Juice Consumption on Blood Pressure in Type 2 Diabetic Patients. Iranian Journal of Endocrinology and Metabolism. 2008; 9 (4) :399-40.
27. Daniel J, Drucker MD. Dipeptidyl Peptidase-4Inhibition and the Treatment of Type 2 Diabetes.Diabeties Care 2007; 30(6): 1335-1343. [DOI:10.2337/dc07-0228]
28. Miyazaki M, Kato M, Tanaka K, Tanaka M,Kohjima M, Nakamura K. Increased hepaticexpression of dipeptidyl peptidase-4 in nonalcoholic fattyliver disease and its association with insulin resistance and glucose metabolism. Mol MedRep 2012; 5:729-33. [DOI:10.3892/mmr.2011.707]
29. Conarello SL, Li Z, Ronan J, Roy RS, Zhu L, JiangG. Mice lacking dipeptidyl peptidase IV areprotected against obesity and insulin resistance. ProcNatl AcadSci USA 2003; 100:6825-30. [DOI:10.1073/pnas.0631828100]
30. Boschmann M, Engeli S, Dobberstein K, BudziarekP, Strauss A, Boehnke J. Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobi-lization and oxidation in type 2 diabetic patients. J ClinEndocrinol Metab 2009; 94:846-52. [DOI:10.1210/jc.2008-1400]
31. Solomon TP, Haus JM, Marchetti CM, Stanley WC, Kirwan JP. Effects of exercisetraining and diet on lipid kinetics during free fatty acidinduced insulin resistance in older obese humans with impaired glucose tolerance. Am J ocrinol Metab 2009; 297:552-9. [DOI:10.1152/ajpendo.00220.2009]
32. Fadini GP, Avogaro A. Cardiovascular effects of DPP-4 inhibition: beyond GLP-1.Vascul Pharmacol: 2011; 55:10-6. [DOI:10.1016/j.vph.2011.05.001]
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Akbarpour M, Fathollahi Shoorabeh F, Mardani M, Amini Majd F. Effects of Eight Weeks of Resistance Training and Consumption of Pomegranate on GLP-1, DPP-4 and Glycemic Statuses in Women with Type 2 Diabetes: A Randomized Controlled Trial. Nutr Food Sci Res 2021; 8 (1) :5-10
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