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:: Volume 7, Issue 2 (Apr-Jun 2020) ::
Nutr Food Sci Res 2020, 7(2): 21-28 Back to browse issues page
Effects of Quercetin Supplementation on Oxidative Stress, Blood Pressure, Aerobic Power, Concentric Pathologic Hypertrophy and Cardiac Function in Men with Hypertension and Coronary Artery Disease After Percutaneous Coronary Intervention: a Randomized, Double-Blind Placebo-Controlled Trial
Khalil Ollah Moonikh , Majid Kashef , Khalil Mahmoudi , Mojtaba Salehpour
PhD student of cardiovascular exercise physiology , kh.moonikh@srttu.edu
Abstract:   (3223 Views)
Background and Objectives: The aim of this study was to investigate possible effects of quercetin supplementation on oxidative stress, blood pressure, aerobic power, concentric pathologic hypertrophy and cardiac function in men with hypertension and coronary artery disease (CAD) after percutaneous coronary intervention (PCI).
Materials and Methods: The present study was a randomized, double-blind clinical trial; in which, 24 men with hypertension and CAD after PCI (aged 40–60 years) were participated. Patients were prescribed quercetin (250 mg/day) or placebo for two months. Plasma total antioxidant capacity (TAC) and malondialdehyde (MDA) were assessed using colorimetric methods as well as left ventricular diastolic dysfunction (LVDD), p wave depression (PWD), ejection fraction (EF) and E/A using echocardiography and WRp using Storer-Davise cycle test. Systolic and diastolic blood pressures were measured before and after the intervention. Data were analyzed using ANCOVA and paired-sample T-test.
Results: Supplementation resulted in a significant improvement in oxidative stress reduction (TAC increased and MDA decreased), systolic and diastolic blood pressures, systolic (EF) and diastolic (E/A) functions and aerobic power, compared to pretest and placebo groups following eight weeks of treatment (p < 0.05). A small decrease in RWT was seen in quercetin group at the end of intervention with no statistical significance (p > 0.05). The RWT was not significantly different between the quercetin and placebo groups (p > 0.05).
Conclusions: Quercetin supplementation can improve oxidative stress, blood pressure, left ventricular function and aerobic power in men with hypertension and CAD after PCI. However, this includes no effects on concentric pathologic hypertrophy. Further studies are necessary to verify effects of quercetin supplementation on left ventricular hypertrophy in humans.
Keywords: Quercetin, Oxidative stress, concentric pathologic hypertrophy, Left ventricular function, blood pressure, CAD
Full-Text [PDF 624 kb]   (1018 Downloads)    
Article type: Research | Subject: Nutrition
Received: 2020/03/13 | Accepted: 2020/04/26 | Published: 2020/05/26
References
1. Kashef M, Mahmoudi K, Salehpour M, Moonikh K. The effect of high-intensity interval training (HIIT) and quercetin supplementation on dimension and functional left ventricular adaptations in men with hypertension and CAD after PCI. Daneshvar Medicine. 2019; 27 (5) :35-48.
2. Suen J, Thomas J, Kranz A, Vun S, Miller M. Effect of Flavonoids on Oxidative Stress and Inflammation in Adults at Risk of Cardiovascular Disease: A Systematic Review. Healthcare (Basel). 2016 Sep 14; 4(3). pii: E69. doi: 10.3390/healthcare4030069 [DOI:10.3390/healthcare4030069]
3. Ramezani A, Moonikh K. Effect of Quercetin Supplementation on Oxidative Stress and Exhaustion in Male Soccer Players. J. Med. Plants. 2017; 2 (62) :136-144.
4. Lauck S, Jonson J, Partner P. Self care behaviour and factors associated with patient outcomes following same day discharge percutaneous coronary intervention. European journal of cardiovascular nursing, 2009; 8, 190-199. [DOI:10.1016/j.ejcnurse.2008.12.002]
5. Juni RP. Duckers HJ. Vanhoutte PM. Virmani R. Moens AL. Oxidative Stress and Pathological Changes After Coronary Artery Interventions. Journal of the American College of Cardiology. 2013; 61(14): 1472-81. [DOI:10.1016/j.jacc.2012.11.068]
6. Leibundgut G. Lee JH. Segev A. Strauss BH and Tsimikas S. Acute and Long-Term Effect of Percutaneous Coronary Intervention on Serially-Measured Oxidative, Inflammatory, and Coagulation Biomarkers in Patients with Stable Angina. J Thromb Thrombolysis. 2016; 41(4): 569-580. doi:10.1007/s11239-016-1351-6. [DOI:10.1007/s11239-016-1351-6]
7. Farzanegi P, Habibian M, Kaftari A. Effect of 6-weeks aerobic exercise training on oxidative stress and enzymatic antioxidants in postmenopausal women with hypertension: Case Study. J Mazandaran Univ Med Sci. 2014; 23(108) :134-136. [Article in Persian]
8. Bowen TS, Eisenkolb S, Drobner J, Fischer T, Werner S, Linke A. High-intensity interval training prevents oxidant-mediated diaphragm muscle weakness in hypertensive mice. FASEB J. 2017 ;31(1):60-71. doi: 10.1096/fj.201600672R. Epub 2016 Sep 20. [DOI:10.1096/fj.201600672r]
9. Weinbrenner T, Cladellas M, Covas MI, et al. High oxidative stress in patients with stable coronary heart disease. Atherosclerosis. 2003; 168(1): 99-106. [DOI:10.1016/S0021-9150(03)00053-4]
10. Azarsiz E, Kayikcioglu M, Payzin S, Yildirim Sozmen E. PON1 activities and oxidative markers of LDL in patients with angiographically proven coronary artery disease. Inter J Cardiol. 2003; 91: 43-51. [DOI:10.1016/S0167-5273(02)00595-8]
11. Serdar Z, Aslan K, Dirican M, Sarandol E, Yesilbursa D, Serdar A. Lipid and protein oxidation and antioxidant status in patients with angiographically proven coronary artery disease. Clin Biochem. 2006; 39: 794-803. [DOI:10.1016/j.clinbiochem.2006.02.004]
12. Jain AK, Mehra NK, Swarnakar NK. Role of Antioxidants for the Treatment of Cardiovascular Diseases: Challenges and Opportunities. Curr Pharm Des. 2015; 21(30):4441-55. [DOI:10.2174/1381612821666150803151758]
13. Baghaiee B, Siahkouhian M, Karimi P and Teixeira M. Weight Gain and Oxidative Stress in Midlife Lead to Pathological Concentric Cardiac Hypertrophy in Sedentary Rats. Journal of Clinical Research in Paramedical Sciences. 2018; Vol 6, No 3, 1-7. [DOI:10.5812/jcrps.79957]
14. Ranjbar K, Nazem F, Nazari A. Effect of Exercise Training and L-arginine on Oxidative Stress and Left Ventricular Function in the Post-ischemic Failing Rat Heart. Cardiovasc Toxicol. 2016 Apr;16(2): 122-9. doi: 10.1007/s12012-015-9319-x. [DOI:10.1007/s12012-015-9319-x]
15. Javadi F, Eghtesadi S, Ahmadzadeh A, Aryaeian N, Zabihiyeganeh M, Foroushani AR, et al. The effect of quercetin on plasma oxidative status, C reactive protein and blood pressure in women with rheumatoid arthritis. Int J Prev Med 2014;5:293 301.
16. Chekalina NI, Shut SV, Trybrat TA, Burmak YH, Petrov YY, Manusha YI, Kazakov YM. Effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease. Wiadomosci lekarskie. 2017; 70(4):707-711.
17. Boots AW, Drent M, de Boer VC, Bast A, Haenen GR. Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clin Nutr. 2011 Aug;30(4):506-12. doi: 10.1016/j.clnu.2011.01.010. Epub 2011 Feb 15. [DOI:10.1016/j.clnu.2011.01.010]
18. Monteiro MM, França-Silva MS, Alves NF, Porpino SK, Braga VA. Quercetin improves baroreflex sensitivity in spontaneously hypertensive rats. Molecules. 2012 Nov 1;17(11):12997-3008. doi: 10.3390/molecules171112997. [DOI:10.3390/molecules171112997]
19. Egert, S. Bosy-Westphal, A. Seiberl, J. Kürbitz, C. Settler, U. Plachta-Danielzik, S. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009; 102(7): 1065-74. [DOI:10.1017/S0007114509359127]
20. Duarte J, Pérez-Palencia R, Vargas F, et al. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol. 2001;133:117-24. [DOI:10.1038/sj.bjp.0704064]
21. Davis JM, Carlstedt CJ, Chen S, Carmichael MD, Murphy EA. The dietary flavonoid quercetin increases VO (2 max) and endurance capacity. Int J Sport Nutr Exerc Metab 2010;20:56 62. [DOI:10.1123/ijsnem.20.1.56]
22. Knab A. M, Shanely R. A, Henson D. A. et al. Influence of quercetin supplementation on disease risk factors in community-dwelling adults. J Am Diet Assoc. 2011;111(4):542-9. [DOI:10.1016/j.jada.2011.01.013]
23. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification. European journal of echocardiography: the journal of the Working Group on Echocardiography of the European Society of Cardiology. 2006;7(2):79-108. [DOI:10.1016/j.euje.2005.12.014]
24. Zare Karizak S, Kashef M, Gaeini AA, Nejatian M. The Comparison of Two Protocol of Interval and Continues Aerobic Training on Level of Concentric Pathologic Hypertrophy and Cardiac Function in Patients after Coronary Artery Bypass Grafting surgery. Journal of Practical Studies of Biosciences in Sport 2016; 5(9): 9-20.
25. Storer TW, Davis JA, and Caozzo VJ. Accurete prediction of Vo2max in cycle ergometry. Med Sci Sport Exerc 1990; 22: 704-712. [DOI:10.1249/00005768-199010000-00024]
26. Chiodo SG, Leopoldini M, Russo N, Toscano M. The inactivation of lipid peroxide radical by quercetin. A theoretical insight. Phys Chem Chem Phys. 2010 Jul 21;12(27):7662-70. [DOI:10.1039/b924521a]
27. Kandhare AD, Raygude KS, Shiva Kumar V, Rajmane AR, Visnagri A, Ghule AE, et al. Ameliorative effects quercetin against impaired motor nerve function, inflammatory mediators and apoptosis in neonatal streptozotocin-induced diabetic neuropathy in rats. Biomedicine & Aging Pathology. 2012; 2(4): 173-186. [DOI:10.1016/j.biomag.2012.10.002]
28. Kumar M, Kasala ER, Bodduluru LN, Kumar V, Lahkar M. Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol-induced acutemyocardial injury in rats. J Biochem Mol Toxicol. 2017 [DOI:10.1002/jbt.21832]
29. 31(1):1-8. doi: 10.1002/jbt.21832. Epub 2016 Aug 15. [DOI:10.1002/jbt.21832]
30. Galisteo M, Garciia-Saura MF, Jimenez R, Villar IC, Vangensteen R, Zarzuelo A, et al. Effects of chronic quercetin treatment on antioxidant defense system and oxidative status of deoxycorticosterone acetate-salt hypertensive rats. Mol Cell Biochem. 2004; 259(1-2): 9-91. [DOI:10.1023/B:MCBI.0000021360.89867.64]
31. Sim GS, Lee BC, Cho HS, et al. Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. Arch Pharm Res. 2007 Mar;30(3):290-8. [DOI:10.1007/BF02977608]
32. da Silva EL, Abdalla DS and Terao J. Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase. IUBMB life. 2000;49(4):289-95. [DOI:10.1080/15216540050033159]
33. Cammerer MA, Gonçalves SC, de Araujo GN, Andrades ME, Lopes A, Wainstein MV. The Effects of a Flavonoid-Rich Diet on Oxidative Stress, Inflammation, and Lipid Profile after Elective Percutaneous Coronary Intervention: A Randomized Clinical Trial. Prev Nutr Food Sci. 2018 [DOI:10.3746/pnf.2018.23.2.108]
34. 23(2):108-114. doi: 10.3746/pnf.2018.23.2.108. Epub 2018 Jun 30. [DOI:10.3746/pnf.2018.23.2.108]
35. Edwards, RL. Lyon, T. Litwin, SE. Rabovsky, A. Symons, JD. Jalili, T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr 2007 137:2405-11. [DOI:10.1093/jn/137.11.2405]
36. Quindry JC, McAnuity SR, Hudson MB, Hosick P, Dumke C, McAnuity LS, et al. Oral quercetin supplementation and blood oxidantive in response to ultramarathon competition. Int J Sport Nutr Exerc Metab. 2008; 18(6): 601-16. [DOI:10.1123/ijsnem.18.6.601]
37. Garcia-Saura MF, Galisteo M, Villar IC, et al. Effects of chronic quercetin treatment in experimental renovascular hypertension. Mol Cell Biochem. 2005 Feb;270(1-2):147-55. [DOI:10.1007/s11010-005-4503-0]
38. Kondratiuk VE, Synytsia YP. Effect of quercetin on the echocardiographic parameters of left ventricular diastolic function in patients with gout and essential hypertension. Wiadomosci lekarskie. 2018; 71(8):1554-1559.
39. Castillo RL, Herrera EA, Gonzalez-Candia A, Reyes-Farias M, Jara ND, Peña JP, Carrasco-Pozo C. Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats. HindawiOxidative Medicine and Cellular Longevity. 2018; 1(1):1-14. doi.org/10.1155/2018/7239123 [DOI:10.1155/2018/7239123]
40. Han JJ, Hao J, Kim CH, Hong JS, Ahn HY, Lee YS. Quercetin prevents cardiac hypertrophy induced by pressure overload in rats. J Vet Med Sci. 2009 Jun;71(6):737-43. [DOI:10.1292/jvms.71.737]
41. Yan L, Zhang JD, Wang B, Lv YJ, Jiang H, et al. Quercetin Inhibits Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats and Inhibits Angiotensin II-Induced H9C2 Cells Hypertrophy by Enhancing PPAR-c Expression and Suppressing AP-1 Activity. PLoS ONE. 2013; 8(9):1-14. [DOI:10.1371/journal.pone.0072548]
42. Ulasova E, Perez J, Bradford G. Hill, Wayne E. Bradley, David W. Garber, Aimee Landar. Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse. Redox Biol. 2013; 1(1): 381-386. [DOI:10.1016/j.redox.2013.07.001]
43. Sriraksa N, Wattanathorn J, Muchimapura S, Tiamkao S, Brown K, Chaisiwamongkol K. Cognitive-enhancing effect of quercetin in a rat model of Parkinson's disease induced by 6-hydroxydopamine. Evid Based Complement Alternat Med. 2012; 2012: 823206. [DOI:10.1155/2012/823206]
44. Zhao L, Wu J, Yang J, Wei J, Gao W, Guo C. Dietary quercetin supplementation increases serum antioxidant capacity and alters hepatic gene expression profile in rats. Exp Biol Med (Maywood). 2011; 236(6): 701-6. [DOI:10.1258/ebm.2011.010258]
45. Lin Y, Liu HL, Fang J, Yu CH, Xiong YK, Yuan K. Anti-fatigue and vasoprotective effects of quercetin-3-O-gentiobiose on oxidative stress and vascular endothelial dysfunction induced by endurance swimming in rats. Food Chem Toxicol. 2014 [DOI:10.1016/j.fct.2014.03.026]
46. 68:290-6. doi: 10.1016/j.fct.2014.03.026. Epub 2014 Mar 29. [DOI:10.1016/j.fct.2014.03.026]
47. Dumke CL, Nieman DC, Utter AC, Rigby MD, Quindry JC, Triplett NT, et al. Quercetin's effect on cycling efficiency and substrate utilization. Appl Physiol Nutr Metab 2009; 34(6): 993-1000. [DOI:10.1139/H09-099]
48. Scholten SD, Sergeev IN. Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners. Open Access J Sports Med. 2013;4:53-61. [DOI:10.2147/OAJSM.S39632]
49. Cureton KJ, Tomporowski PD, Singhal A, Pasley JD, Bigelman KA, Lambourne K, et al. Dietary quercetin supplementation is not ergogenic in untrained men. J Appl Physiol 2009;107:1095 104. [DOI:10.1152/japplphysiol.00234.2009]
50. Ganio MS, Armstrong LE, Johnson EC, Klau JF, Ballard KD, Michniak Kohn B, et al. Effect of quercetin supplementation on maximal oxygen uptake in men and women. J Sports Sci 2010;28:201 8. [DOI:10.1080/02640410903428558]
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Moonikh K O, Kashef M, Mahmoudi K, Salehpour M. Effects of Quercetin Supplementation on Oxidative Stress, Blood Pressure, Aerobic Power, Concentric Pathologic Hypertrophy and Cardiac Function in Men with Hypertension and Coronary Artery Disease After Percutaneous Coronary Intervention: a Randomized, Double-Blind Placebo-Controlled Trial. Nutr Food Sci Res 2020; 7 (2) :21-28
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Nutrition and Food Sciences Research
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