Assisstant Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Abstract: (1093 Views)
Background and Objectives: Diabetes mellitus is a common chronic disease worldwide. Although it is treated with a number of methods including diet therapy, hypoglycemic agents, insulin and some herbs, its’ prevalence and complications are rapidly increasing. Chicory intybus has been used as a traditional diabetes treatment in Iran, Egypt, and other countries but there is a lack of convincing evidence on its effect. This study was designed to evaluate the effects of aqueous extract of chicory leaf on body weight, serum insulin, glucose and lipids in diabetic male Wistar rats. Materials and Methods: Forty male Wistar rats were divided into five groups. Four groups were given streptozotocin intraperitoneally to induce diabetes. Three of the diabetic groups received varying concentrations of chicory aqueous extract for three weeks (12, 25 and 50 mg /kg body weight). The forth diabetic group and the non-diabetic group received distilled water (diabetic and healthy control groups respectively). Fasting blood glucose, serum triglyceride (TG), total cholesterol (TC), LDL and HDL levels were measured after 3 weeks of treatment. Results: The results did not show any significant effects on fasting blood glucose (173.5±126, 154.5±100, 247.7±46, 170.7±150.8 mg/dL) and serum lipids; LDL(19.5±7.7, 26.4±6.7, 24.2±7.7, 24.7±6.8 mg/dL), HDL(41±22.8, 41.2±12, 44.7±12.1, 40±4.6 mg/dL), TG (103.5±35, 80.4±53.8, 111±70, 94±8.9 mg/dL) and TC (76.2±27.3, 80.4±53.8, 77±18.4, 72.7±15 mg/dl) in Streptozotocin induced diabetic groups receiving 12, 25 and 50 mg/kg aqueous chicory extract and diabetic control groups respectively. Conclusions: Chicory leaf aqueous extract had no significant effects on serum glucose and lipids of streptozotocin-induced diabetic rats.
Type of Study: Research |
Subject: Special Received: 2017/07/16 | Accepted: 2017/10/14 | Published: 2017/10/14
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1. Nanditha A, Ma RC, Ramachandran A, Snehalatha C, Chan JC, Chia KS, et al. Diabetes in Asia and the Pacific: Implications for the Global Epidemic. Diabetes Care. 2016;39(3):472-85. [DOI:10.2337/dc15-1536] [PMID]
2. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives. Nature reviews Endocrinology. 2012;8(4):228-36. [DOI:10.1038/nrendo.2011.183] [PMID]
3. Sadeghi M, Roohafza H, Shirani S, Poormoghadas M, Kelishadi R, Baghaii A, et al. Diabetes and associated cardiovascular risk factors in Iran: the Isfahan Healthy Heart Programme. Annals of the Academy of Medicine, Singapore. 2007;36(3):175-80. [PMID]
4. Larejani BZ, F. Epidemiology of diabetes melitus in Iran. Iranian Journal of Diabetes and Metabolism. 2001;1(1):1-8.
5. Larijani B, Abolhasani F, Mohajeri-Tehrani M, Tabtabaie O. Prevalence of diabetes mellitus in Iran in 2000. Iranian Journal of Diabetes and Metabolism. 2005;4(3):75-83.
6. Safari M, Yazdanpanah B, Yazdanpanah B, Mobasheri A. A population-based screening of type 2 diabetes in high-risk population of Yasuj, Iran. Journal of health, population, and nutrition. 2014;32(4):677-86. [PMID] [PMCID]
7. Nentwich MM, Ulbig MW. Diabetic retinopathy - ocular complications of diabetes mellitus. World journal of diabetes. 2015;6(3):489-99. [DOI:10.4239/wjd.v6.i3.489] [PMID] [PMCID]
8. Viswanathan V. Preventing microvascular complications in type 1 diabetes mellitus. Indian journal of endocrinology and metabolism. 2015;19(Suppl 1):S36-8. [DOI:10.4103/2230-8210.155382] [PMID] [PMCID]
9. Ko CH, Yi S, Ozaki R, Cochrane H, Chung H, Lau W, et al. Healing effect of a two-herb recipe (NF3) on foot ulcers in Chinese patients with diabetes: a randomized double-blind placebo-controlled study. Journal of diabetes. 2014;6(4):323-34. [DOI:10.1111/1753-0407.12117] [PMID]
10. Kibiti CM, Afolayan AJ. Herbal therapy: A review of emerging pharmacological tools in the management of diabetes mellitus in Africa. Pharmacognosy Magazine. 2015;11(Suppl 2):S258-S74. [DOI:10.4103/0973-1296.166046] [PMID] [PMCID]
11. Street RA, Sidana J, Prinsloo G. Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology. Evidence-based complementary and alternative medicine : eCAM. 2013;2013:579319. [DOI:10.1155/2013/579319] [PMID] [PMCID]
12. Nasiri A, Ziamajidi N, Behrouj H, Abbasalipourkabir R, Dehghan A. The effects of aqueous extract of chicory root on steatosis, lipid profile and liver damage enzyme markers in tamoxifen-treated rats. Molecular and Biochemical Diagnosis (Journal). 2014;1(3):185-94.
13. Suntar I, Kupeli Akkol E, Keles H, Yesilada E, Sarker SD, Baykal T. Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: stepwise isolation of an active component by in vivo bioassay and its mode of activity. Journal of ethnopharmacology. 2012;143(1):299-309. [DOI:10.1016/j.jep.2012.06.036] [PMID]
14. Tavakkoli-Kakhki M, Eslami S, Motavasselian M. Nutrient-rich versus nutrient-poor foods for depressed patients based on Iranian Traditional Medicine resources. Avicenna journal of phytomedicine. 2015;5(4):298-308. [PMID] [PMCID]
15. Ahmad L, Semotiuk A, Zafar M, Ahmad M, Sultana S, Liu QR, et al. Ethnopharmacological documentation of medicinal plants used for hypertension among the local communities of DIR Lower, Pakistan. Journal of ethnopharmacology. 2015;175:138-46. [DOI:10.1016/j.jep.2015.09.014] [PMID]
16. Amiri MS, Joharchi MR, Taghavizadehyazdi ME. Ethno-medicinal plants used to cure jaundice by traditional healers of mashhad, iran. Iranian journal of pharmaceutical research : IJPR. 2014;13(1):157-62. [PMID] [PMCID]
17. Mohammadi Q, Minae MB, Somi MH, Mosaddegh M, Kamalinejad M. Novel use of chicory for the treatment of hiccups in liver obstruction: in Iranian traditional medicine. Iranian Red Crescent medical journal. 2013;15(11):e6647. [DOI:10.5812/ircmj.6647] [PMID] [PMCID]
18. Judžentienė A, Būdienė J. Volatile constituents from aerial parts and roots of Cichorium intybus L. (chicory) grown in Lithuania. Chemija. 2008;19:25-8.
19. Akash MS, Rehman K, Chen S. Spice plant Allium cepa: dietary supplement for treatment of type 2 diabetes mellitus. Nutrition. 2014;30(10):1128-37. [DOI:10.1016/j.nut.2014.02.011] [PMID]
20. Boaduo NK, Katerere D, Eloff JN, Naidoo V. Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus in South Africa using in vitro methods. Pharmaceutical biology. 2014;52(6):756-61. [DOI:10.3109/13880209.2013.869828] [PMID]
21. Ghosh S, More P, Derle A, Patil AB, Markad P, Asok A, et al. Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity against alpha-amylase and alpha-glucosidase. PloS one. 2014;9(9):e106039. [DOI:10.1371/journal.pone.0106039] [PMID] [PMCID]
22. Li Y, Li JJ, Wen XD, Pan R, He YS, Yang J. Metabonomic analysis of the therapeutic effect of Potentilla discolor in the treatment of type 2 diabetes mellitus. Molecular bioSystems. 2014;10(11):2898-906. [DOI:10.1039/C4MB00278D] [PMID]
23. Medagama AB, Bandara R. The use of complementary and alternative medicines (CAMs) in the treatment of diabetes mellitus: is continued use safe and effective? Nutrition journal. 2014;13:102. [DOI:10.1186/1475-2891-13-102] [PMID] [PMCID]
24. Parikh NH, Parikh PK, Kothari C. Indigenous plant medicines for health care: treatment of Diabetes mellitus and hyperlipidemia. Chinese journal of natural medicines. 2014;12(5):335-44. [DOI:10.1016/S1875-5364(14)60041-8]
25. Sales DS, Carmona F, de Azevedo BC, Taleb-Contini SH, Bartolomeu AC, Honorato FB, et al. Eugenia punicifolia (Kunth) DC. as an adjuvant treatment for type-2 diabetes mellitus: a non-controlled, pilot study. Phytotherapy research : PTR. 2014;28(12):1816-21. [DOI:10.1002/ptr.5206] [PMID]
26. Xin QQ, Liu Y, Yang L, Fu CG, Chen KJ. [Ginkgo preparations of Chinese medicine and treatment of diabetes: mechanisms and clinical applications]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014;39(23):4509-15. [PMID]
27. Abbas ZK, Saggu S, Sakeran MI, Zidan N, Rehman H, Ansari AA. Phytochemical, antioxidant and mineral composition of hydroalcoholic extract of chicory (Cichorium intybus L.) leaves. Saudi journal of biological sciences. 2015;22(3):322-6. [DOI:10.1016/j.sjbs.2014.11.015] [PMID] [PMCID]
28. Pushparaj PN, Low HK, Manikandan J, Tan BK, Tan CH. Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats. Journal of ethnopharmacology. 2007;111(2):430-4. [DOI:10.1016/j.jep.2006.11.028] [PMID]
29. Ziamajidi N, Khaghani S, Hassanzadeh G, Vardasbi S, Ahmadian S, Nowrouzi A, et al. Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARalpha and SREBP-1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013;58:198-209. [DOI:10.1016/j.fct.2013.04.018] [PMID]
30. Bakhtiuary Z. Herbal medicines in diabetes. Iranian journal of diabetes and obesity. 2011;3(2):88-95.
31. Carvalho CA, Camargo AM, Cagnon VH, Padovani CR. Effects of experimental diabetes on the structure and ultrastructure of the coagulating gland of C57BL/6J and NOD mice. Anat Rec A Discov Mol Cell Evol Biol. 2003;270(2):129-36. [DOI:10.1002/ar.a.10014] [PMID]
32. Kim M, Shin HK. The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats. The Journal of nutrition. 1998;128(10):1731-6. [PMID]
33. Ghamarian A, Abdollahi M, Su X, Amiri A, Ahadi A, Nowrouzi A. Effect of chicory seed extract on glucose tolerance test (GTT) and metabolic profile in early and late stage diabetic rats. DARU Journal of Pharmaceutical Sciences. 2012;20(1):56. [DOI:10.1186/2008-2231-20-56] [PMID] [PMCID]
34. Tousch D, Lajoix AD, Hosy E, Azay-Milhau J, Ferrare K, Jahannault C, et al. Chicoric acid, a new compound able to enhance insulin release and glucose uptake. Biochem Biophys Res Commun. 2008;377(1):131-5. [DOI:10.1016/j.bbrc.2008.09.088] [PMID]
35. Wight WA, Niekerk JV. Determination of reducing sugars, sucrose and insulin. Journal of Agriculture and Food Chemistry. 1983;31:282–5. [DOI:10.1021/jf00116a024]